Ultrasound diagnosis and follow‐up of gestational trophoblastic disease
Ultrasound diagnosis and follow‐up of gestational trophoblastic disease
复制标题
妊娠滋养细胞疾病的超声诊断及随访
DOI：
10.1046/j.1469-0705.1998.11050367.x
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发表时间：
1998
影响因子：
7.1
通讯作者：
E. Jauniaux
中科院分区：
文献类型：
--
作者：
E. Jauniaux
妊娠滋养细胞疾病是一个通常用于指源自胎盘滋养细胞的一系列相关疾病的术语。这些组织学上不同的疾病实体包括完全性、部分性和侵袭性葡萄胎、胎盘部位滋养细胞肿瘤和绒毛膜癌。随着用于监测妊娠滋养细胞疾病的人绒毛膜促性腺激素 (hCG) 灵敏检测方法的出现以及新的化疗方法的出现，大多数被诊断患有妊娠滋养细胞疾病的女性都得到了随访，并且可以在出现严重并发症之前得到治疗。对各种形式的妊娠滋养细胞疾病的发病率的估计各不相同，主要是因为很少有国家有登记，而且在流行病学研究中，完全性葡萄胎和部分性葡萄胎常常被视为一个单一的实体。此外，表现为流产的完全或部分葡萄胎很可能会逃避检测。事实上，绝大多数完全性葡萄胎和部分性葡萄胎在妊娠前三个月自然流产，葡萄胎的发生率估计为每 41 次流产中就有 1 例2。在葡萄胎妊娠排空后，经常观察到滋养层栓塞引起的肺部并发症3，这些患者的预后取决于症状的严重程度。早期诊断可以降低严重并发症的风险，特别是呼吸衰竭的风险。超声检查已经取代了所有其他早期筛查和鉴别诊断子宫内葡萄胎的方法4。本综述旨在评估超声和多普勒检查在妊娠滋养细胞疾病患者的诊断、随访和管理中的作用。
Gestational trophoblastic disease is a term commonly applied to a spectrum of interrelated diseases originating from the placental trophoblast1. These histologically distinct disease entities include complete, partial and invasive moles, placental site trophoblastic tumors and choriocarcinomas. With the advent of a sensitive assay for human chorionic gonadotropin (hCG) for monitoring gestational trophoblastic disease and new approaches to chemotherapy, most women diagnosed as having gestational trophoblastic disease are followed up and can be treated before the development of severe complications. Estimates of the incidence of the various forms of gestational trophoblastic disease vary, mainly because few countries have registries, and complete and partial moles have often been treated as a single entity in epidemiological studies. Furthermore, complete or partial hydatidiform moles presenting as miscarriages are likely to escape detection. Indeed, the vast majority of complete and partial moles abort spontaneously during the first trimester of pregnancy and the incidence of molar pregnancies has been estimated to be 1 per 41 miscarriages2.Pulmonary complications due to trophoblastic embolization are frequently observed following the evacuation of a molar pregnancy3 and the prognosis for these patients depends upon the severity of the symptoms. Early diagnosis reduces the risk of severe complications and, in particular, of respiratory failure. Ultrasonography has replaced all other means for early screening and for establishing the differential diagnosis of molar pregnancies in utero4. The current review was undertaken to evaluate the role of ultrasound and Doppler examination in the diagnosis, follow-up and management of patients with gestational trophoblastic disease.
影响因子：
7.2
作者：
Fine,C;Bundy,AL;Berkowitz,RS;Boswell,SB;Berezin,AF;Doubilet,PM
通讯作者：
Doubilet,PM
137 个新鲜水肿胎盘的流式细胞术研究：葡萄胎类型与核 DNA 倍体之间的相关性。
影响因子：
7.2
作者：
Lage,JM;Mark,SD;Roberts,DJ;Goldstein,DP;Bernstein,MR;Berkowitz,RS
通讯作者：
Berkowitz,RS