Mechanotransduction, nanotechnology, and nanomedicine.
Mechanotransduction, nanotechnology, and nanomedicine.
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力传导、纳米技术和纳米医学
DOI：
10.7555/jbr.34.20200063
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发表时间：
2020-07-31
影响因子：
2.3
通讯作者：
Nakamura F
中科院分区：
文献类型：
--
作者：
Liu X;Nakamura F
机械力传递是将机械力转化为生物化学信号的过程，对人类的发育和生理至关重要。它可以在从整个身体、器官、组织、细胞器到分子的所有水平上观察到。失调导致各种疾病，如肌营养不良症、高血压引起的血管和心脏肥大、骨修复改变和细胞死亡。由于机械力传导发生在纳米尺度上，纳米科学和应用纳米技术是研究机械力传导的分子机制和途径的有力工具。原子力显微镜、磁镊和光镊常用于单分子水平的力测量和操纵。力也被用于控制细胞，通过特定类型的纳米材料进行形貌和机械组织工程。机械转导研究将成为纳米医学下的一个子学科越来越重要。本文综述了近年来在纳米医学发展中发挥越来越重要作用的力学信号转导过程中分子和细胞水平上的力测量和操纵技术。
Mechanotransduction, a conversion of mechanical forces into biochemical signals, is essential for human development and physiology. It is observable at all levels ranging from the whole body, organs, tissues, organelles down to molecules. Dysregulation results in various diseases such as muscular dystrophies, hypertension-induced vascular and cardiac hypertrophy, altered bone repair and cell deaths. Since mechanotransduction occurs at nanoscale, nanosciences and applied nanotechnology are powerful for studying molecular mechanisms and pathways of mechanotransduction. Atomic force microscopy, magnetic and optical tweezers are commonly used for force measurement and manipulation at the single molecular level. Force is also used to control cells, topographically and mechanically by specific types of nano materials for tissue engineering. Mechanotransduction research will become increasingly important as a sub-discipline under nanomedicine. Here we review nanotechnology approaches using force measurements and manipulations at the molecular and cellular levels during mechanotransduction, which has been increasingly play important role in the advancement of nanomedicine.
DOI：
10.3390/life4020267
发表时间：
2014-05-30
期刊：
Life (Basel, Switzerland)
影响因子：
--
作者：
Bradamante S;Barenghi L;Maier JA
通讯作者：
Maier JA
DOI：
10.2174/1874325000802010155
发表时间：
2008-12-29
期刊：
The open orthopaedics journal
影响因子：
--
作者：
Shim JW;Wise DA;Elder SH
通讯作者：
Elder SH