Gut-Microbial Metabolites, Probiotics and Their Roles in Type 2 Diabetes.
Gut-Microbial Metabolites, Probiotics and Their Roles in Type 2 Diabetes.
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肠道微生物代谢物、益生菌及其在 2 型糖尿病中的作用
DOI：
10.3390/ijms222312846
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发表时间：
2021-11-27
影响因子：
5.6
通讯作者：
Wong HLX
中科院分区：
文献类型：
--
作者：
Zhai L;Wu J;Lam YY;Kwan HY;Bian ZX;Wong HLX
2型糖尿病(T2D)是一种全球流行的代谢性疾病，由胰岛素抵抗(IR)和胰岛素分泌受损引起的高血糖水平定义。了解胰岛素的作用机制对于继续开发治疗T2D的新的治疗策略具有重要意义。肠道微生物区系紊乱在T2D患者中被广泛发现，并有助于IR的发生。本文综述了肠道微生物代谢产物，包括气态产物、支链氨基酸(BCAAs)产物、芳香族氨基酸(AAAs)产物、胆汁酸(BA)产物、胆碱产物和细菌毒素在调节T2D胰岛素敏感性中的病理作用。随后，我们总结了以益生菌为基础的治疗T2D的策略，重点是在动物和人类研究中调节肠道微生物区系。这些结果表明肠道微生物代谢产物参与了T2D的发病过程，补充益生菌可能通过调节肠道微生物区系来减轻T2D的IR。
Type 2 diabetes (T2D) is a worldwide prevalent metabolic disorder defined by high blood glucose levels due to insulin resistance (IR) and impaired insulin secretion. Understanding the mechanism of insulin action is of great importance to the continuing development of novel therapeutic strategies for the treatment of T2D. Disturbances of gut microbiota have been widely found in T2D patients and contribute to the development of IR. In the present article, we reviewed the pathological role of gut microbial metabolites including gaseous products, branched-chain amino acids (BCAAs) products, aromatic amino acids (AAAs) products, bile acids (BA) products, choline products and bacterial toxins in regulating insulin sensitivity in T2D. Following that, we summarized probiotics-based therapeutic strategy for the treatment of T2D with a focus on modulating gut microbiota in both animal and human studies. These results indicate that gut-microbial metabolites are involved in the pathogenesis of T2D and supplementation of probiotics could be beneficial to alleviate IR in T2D via modulation of gut microbiota.
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DOI：
10.1007/164_2019_238
发表时间：
2019-01-01
期刊：
BILE ACIDS AND THEIR RECEPTORS
影响因子：
--
作者：
Fiorucci, Stefano;Distrutti, Eleonora
通讯作者：
Distrutti, Eleonora
影响因子：
5.8
作者：
Chiang JY
通讯作者：
Chiang JY
影响因子：
5.6
作者：
Bagarolli, Renata A.;Tobar, Natalia;Saad, Mario J. A.
通讯作者：
Saad, Mario J. A.
影响因子：
6.3
作者：
Camargo, Antonio;Jimenez-Lucena, Rosa;Lopez-Miranda, Jose
通讯作者：
Lopez-Miranda, Jose
影响因子：
4.8
作者：
Chung, Soonkyu;LaPoint, Kathleen;McIntosh, Michael K.
通讯作者：
McIntosh, Michael K.