Recent advances in alveolar biology: evolution and function of alveolar proteins.
Recent advances in alveolar biology: evolution and function of alveolar proteins.
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DOI：
10.1016/j.resp.2010.04.023
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发表时间：
2010-08-31
影响因子：
2.3
通讯作者：
Possmayer, Fred
中科院分区：
文献类型：
--
作者：
Orgeig, Sandra;Hiemstra, Pieter S.;Veldhuizen, Edwin J. A.;Casals, Cristina;Clark, Howard W.;Haczku, Angela;Knudsen, Lars;Possmayer, Fred
关键词：
Surfactant proteinsSP-ASP-CSP-DBinding affinityOligomerizationDeficiencyAlveolar proteinsCollectinsCathelicidinsDefensinsInnate host defenceHemagglutination inhibition activityBacterial aggregationPro-inflammatory responseAnti-inflammatory responseAirwaysAllergic responseSensitizationSurfactant homeostasisAlveolar lipoproteinosisType II cell hypertrophy and hyperplasiaLamellar body size and number
本文就肺泡蛋白的进化和功能作一综述。由于压力/体积变化和外来病原体，肺分别面临物理和环境挑战。肺表面活性剂系统通过两组表面活性剂蛋白-调节脂质界面吸附的小分子量疏水性SP SP-B和-C，以及作为能够抑制外来病原体的表面活性剂聚集蛋白的大分子量亲水性SP SP-A和-D，在保护肺免受这些挑战方面是不可或缺的。进一步帮助肺部宿主防御的是跨生物界表达的非表面活性剂聚集素和抗微生物肽。链接到第一次研讨会会议，其中强调的分子结构和生物物理功能的表面活性剂脂质和蛋白质，这篇评论开始讨论的温度和静水压力的作用，在塑造的进化SP-C在哺乳动物。过渡到肺泡在先天宿主防御中的作用，我们讨论了抗菌肽，防御素和cathelicidins的结构，功能和调节。我们描述了最近发现的新的禽聚集素，并提供证据，他们在预防流感感染的作用。随后讨论了SP-A和SP-D在介导肺泡表面的宿主防御以及在介导气道的炎症和过敏反应中的作用。最后，我们讨论了使用的肺部疾病的动物模型，包括敲除，以了解这些蛋白质在启动和/或永久性疾病的目的，开发新的治疗策略的作用。
This review is focused on the evolution and function of alveolar proteins. The lung faces physical and environmental challenges, due to changing pressures/volumes and foreign pathogens, respectively. The pulmonary surfactant system is integral in protecting the lung from these challenges via two groups of surfactant proteins – the small molecular weight hydrophobic SPs, SP-B and -C, that regulate interfacial adsorption of the lipids, and the large hydrophilic SPs, SP-A and -D, which are surfactant collectins capable of inhibiting foreign pathogens. Further aiding pulmonary host defence are non-surfactant collectins and antimicrobial peptides that are expressed across the biological kingdoms. Linking to the first symposium session, which emphasised molecular structure and biophysical function of surfactant lipids and proteins, this review begins with a discussion of the role of temperature and hydrostatic pressure in shaping the evolution of SP-C in mammals. Transitioning to the role of the alveolus in innate host defence we discuss the structure, function and regulation of antimicrobial peptides, the defensins and cathelicidins. We describe the recent discovery of novel avian collectins and provide evidence for their role in preventing influenza infection. This is followed by discussions of the roles of SP-A and SP-D in mediating host defence at the alveolar surface and in mediating inflammation and the allergic response of the airways. Finally we discuss the use of animal models of lung disease including knockouts to develop an understanding of the role of these proteins in initiating and/or perpetuating disease with the aim of developing new therapeutic strategies.
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DOI：
10.1073/pnas.95.20.11869
发表时间：
1998-09-29
影响因子：
11.1
作者：
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DOI：
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影响因子：
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发表时间：
2008-02-01
影响因子：
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DOI：
10.1165/rcmb.2003-0091oc
发表时间：
2004-03-01
影响因子：
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作者：
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