Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction.
Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction.
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DOI：
10.4049/jimmunol.0900039
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发表时间：
2009-06-15
期刊：
影响因子：
--
通讯作者：
Koller BH
中科院分区：
文献类型：
--
作者：
Cyphert JM;Kovarova M;Allen IC;Hartney JM;Murphy DL;Wess J;Koller BH
肥大细胞是保护环境和机体之间界面的重要哨兵：该界面完整性的破坏可导致释放过多的介质，这些介质参与外源因子，招募白细胞，并启动生物体的适应性生理变化。虽然这些能力使肥大细胞在免疫防御中发挥重要作用，但也使它们成为哮喘等疾病发病机制的重要贡献者。肥大细胞介质诱导平滑肌生理学的显著变化，并且平滑肌表达这些因子的受体表明它们直接起作用以启动收缩。与此观点相反，我们在这里表明，肥大细胞介导的支气管收缩，观察到只有在动物与完整的肺神经支配和血清素的释放是需要这个行动。虽然感觉神经元的消融并不限制支气管收缩，但在胆碱能途径受损的小鼠中，抗原激发后的收缩是不存在的。将肥大细胞功能与胆碱能系统联系起来可能提供了调节这些常驻免疫细胞功能以适应肺生理学的重要手段，但也可能在肥大细胞脱粒期间提供针对危及生命的过敏反应的保护措施。
Mast cells are important sentinels guarding the interface between the environment and the body: a breach in the integrity of this interface can lead to the release of a plethora of mediators which engage the foreign agent, recruit leukocytes, and initiate adaptive physiological changes in the organism. While these capabilities make mast cells critical players in immune defense, it also makes them important contributors to the pathogenesis of diseases such as asthma. Mast cell mediators induce dramatic changes in smooth muscle physiology, and the expression of receptors for these factors by smooth muscle suggests that they act directly to initiate constriction. Contrary to this view, we show here that mast cell-mediated bronchoconstriction is observed only in animals with intact innervation of the lung and that serotonin release alone is required for this action. While ablation of sensory neurons does not limit bronchoconstriction, constriction after antigen challenge is absent in mice in which the cholinergic pathways are compromised. Linking mast cell function to the cholinergic system likely provides an important means of modulating the function of these resident immune cells to physiology of the lung, but may also provide a safeguard against life-threatening anaphylaxis during mast cell degranulation.
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DOI：
10.1084/jem.184.4.1483
发表时间：
1996-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
影响因子：
29.4
作者：
Barbara, Giovanni;Wang, Bingxian;Corinaldesi, Roberto
通讯作者：
Corinaldesi, Roberto
影响因子：
3.6
作者：
Bengel, D;Murphy, DL;Lesch, KP
通讯作者：
Lesch, KP
DOI：
10.1164/ajrccm/138.6_pt_2.s31
发表时间：
1988-12-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
BIENENSTOCK, J;PERDUE, M;MARSHALL, J
通讯作者：
MARSHALL, J
影响因子：
5.3
作者：
Chen, JJ;Li, ZS;Gershon, MD
通讯作者：
Gershon, MD