Neuroprotective effect of carnosine on necrotic cell death in PC12 cells
Neuroprotective effect of carnosine on necrotic cell death in PC12 cells
复制标题
肌肽对 PC12 细胞坏死细胞死亡的神经保护作用
DOI：
10.1016/j.neulet.2006.12.005
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发表时间：
2007-03
影响因子：
2.5
通讯作者：
中科院分区：
文献类型：
--
作者：
The nervous tissue of many vertebrates, including humans, can synthesize β-alanyl-l-histidine (carnosine). The biological functions of carnosine are still open to question, although several theories supported by strong experimental data have been proposed. The objective of this study was to examine the effects of carnosine on neurotoxicity in differentiated rat pheochromocytoma (PC12) cells. Neurotoxicity was induced by N-methyl-d-aspartate (NMDA), which caused time- and concentration-dependent cell death as measured by MTT and LDH assays. Pretreatment with carnosine significantly prevented the neurotoxicity in a concentration-dependent manner. The protective effect of carnosine was antagonized by the H1receptor antagonist pyrilamine, but not by the H2receptor antagonist cimetidine. In addition, α-fluoromethylhistidine, a histidine decarboxylase inhibitor, slightly reversed the protective action of carnosine. These results indicate that carnosine can effectively protect against NMDA-induced necrosis in PC12 cells, and its protection may in part be due to the activation of the postsynaptic histamine H1receptor. The study suggests that carnosine may be an endogenous protective factor and calls for its further study as a new anti-excitotoxic agent.
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影响因子：
7.3
作者：
Anne O'Dowd;David J. Miller
通讯作者：
Anne O'Dowd;David J. Miller
影响因子：
4.7
作者：
Vizuete, ML;Merino, M;Machado, A
通讯作者：
Machado, A
DOI：
10.1111/j.1749-6632.1998.tb09890.x
发表时间：
1998-01-01
期刊：
TOWARDS PROLONGATION OF THE HEALTHY LIFE SPAN
影响因子：
--
作者：
Hipkiss, AR;Preston, JE;Abbott, NJ
通讯作者：
Abbott, NJ
影响因子：
2.5
作者：
Lesort, M;Esclaire, F;Hugon, J
通讯作者：
Hugon, J
DOI：
--
发表时间：
2000-07
期刊：
Biochemistry. Biokhimiia
影响因子：
--
作者：
P. Trombley;M. Horning;L. J. Blakemore
通讯作者：
P. Trombley;M. Horning;L. J. Blakemore