Effect of a single dose of citalopram on amygdala response to emotional faces.
Effect of a single dose of citalopram on amygdala response to emotional faces.
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DOI：
10.1192/bjp.bp.108.056093
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Harmer CJ
中科院分区：
文献类型：
--
作者：
Murphy SE;Norbury R;O'Sullivan U;Cowen PJ;Harmer CJ
背景选择性5-羟色胺再摄取抑制剂(SSRI)通常被认为有几周的临床效果延迟。然而，最近的报告表明，它们的治疗开始时间可能要早得多。杏仁核反应性的降低与SSRIs的治疗作用有关。目的是研究单剂量SSRI对杏仁核对情绪面孔反应的影响。方法26名健康志愿者随机分为两组，分别口服单剂量西酞普兰(20 Mg)或安慰剂。3h后用功能磁共振成像评估对面部表情加工的影响。结果与安慰剂相比，接受西酞普兰治疗的志愿者对恐惧面部表情的杏仁核反应显著降低。结论SSRI对杏仁核对威胁反应的即刻效应支持抗抑郁药比传统认为的更早出现治疗相关效应的观点。
Background Selective serotonin reuptake inhibitors (SSRIs) are typically thought to have a delay of several weeks in the onset of their clinical effects. However, recent reports suggest they may have a much earlier therapeutic onset. A reduction in amygdala responsivity has been implicated in the therapeutic action of SSRIs. Aims To investigate the effect of a single dose of an SSRI on the amygdala response to emotional faces. Method Twenty-six healthy volunteers were randomised to receive a single oral dose of citalopram (20 mg) or placebo. Effects on the processing of facial expressions were assessed 3 h later using functional magnetic resonance imaging. Results Volunteers treated with citalopram displayed a significantly reduced amygdala response to fearful facial expressions compared with placebo. Conclusions Such an immediate effect of an SSRI on amygdala responses to threat supports the idea that antidepressants have an earlier onset of therapeutically relevant effects than conventionally thought.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
DOI：
10.1073/pnas.172403899
发表时间：
2002-08-20
影响因子：
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作者：
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