Influence of Implantation Depth on the Performance of Intracortical Probe Recording Sites.
Influence of Implantation Depth on the Performance of Intracortical Probe Recording Sites.
复制标题
DOI：
10.3390/mi12101158
复制
发表时间：
2021-09-27
期刊：
影响因子：
3.4
通讯作者：
Patnaik SS
中科院分区：
文献类型：
--
作者：
Usoro JO;Dogra K;Abbott JR;Radhakrishna R;Cogan SF;Pancrazio JJ;Patnaik SS
微电极阵列（MEA）能够记录皮层神经元的电活动，这对基础神经科学和神经假体应用具有重要意义。MEA技术的设计空间非常宽，其中装置可以根据单片柄的数量以及微电极位置的放置而变化。在本研究中，我们研究了两种不同的MEA配置之间的记录能力的差异：单柄（SS）和多柄（MS），这两种都包括16个记录点植入大鼠运动皮层。我们观察到在8周留置期内活性微电极部位的比例存在显著差异，其中SS器械表现出一致的记录活性的能力，而MS阵列在植入后2周内显示出活性显著降低。此外，这种差异被发现是依赖于深度的微电极网站位于和可能介导的解剖异质性，以及抑制性神经元内的皮层层的分布。我们的研究结果表明，植入深度的皮质内的微电极需要考虑相对于慢性性能表征。
Microelectrode arrays (MEAs) enable the recording of electrical activity from cortical neurons which has implications for basic neuroscience and neuroprosthetic applications. The design space for MEA technology is extremely wide where devices may vary with respect to the number of monolithic shanks as well as placement of microelectrode sites. In the present study, we examine the differences in recording ability between two different MEA configurations: single shank (SS) and multi-shank (MS), both of which consist of 16 recording sites implanted in the rat motor cortex. We observed a significant difference in the proportion of active microelectrode sites over the 8-week indwelling period, in which SS devices exhibited a consistent ability to record activity, in contrast to the MS arrays which showed a marked decrease in activity within 2 weeks post-implantation. Furthermore, this difference was revealed to be dependent on the depth at which the microelectrode sites were located and may be mediated by anatomical heterogeneity, as well as the distribution of inhibitory neurons within the cortical layers. Our results indicate that the implantation depth of microelectrodes within the cortex needs to be considered relative to the chronic performance characterization.
登录
查看更多内容
基于层状硅的慢性植入平面硅探针的机械故障模式，用于层流记录。
影响因子：
14
作者：
Kozai, Takashi D. Y.;Catt, Kasey;Li, Xia;Gugel, Zhannetta V.;Olafsson, Valur T.;Vazquez, Alberto L.;Cui, X. Tracy
通讯作者：
Cui, X. Tracy
影响因子：
6.1
作者：
Keating CE;Cullen DK
通讯作者：
Cullen DK
影响因子：
3.4
作者：
Deku, Felix;Frewin, Christopher L.;Cogan, Stuart F.
通讯作者：
Cogan, Stuart F.
影响因子：
2.4
作者：
LaPlaca, MC;Cullen, DK;Cargill, RS
通讯作者：
Cargill, RS
影响因子：
4.6
作者：
Guitchounts, Grigori;Cox, David
通讯作者：
Cox, David