A PET-CT study on the specificity of acupoints through acupuncture treatment in migraine patients.
A PET-CT study on the specificity of acupoints through acupuncture treatment in migraine patients.
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针刺治疗偏头痛患者穴位特异性的PET-CT研究
DOI：
10.1186/1472-6882-12-123
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发表时间：
2012-08-15
影响因子：
--
通讯作者：
Liang F
中科院分区：
文献类型：
--
作者：
Yang J;Zeng F;Feng Y;Fang L;Qin W;Liu X;Song W;Xie H;Chen J;Liang F
研究背景在针灸研究领域，穴位特异性问题日益受到关注，但穴位特异性是否存在尚无统一的结论。此外，大多数以前的针灸神经影像学研究已经使用健康受试者进行。方法将30例偏头痛患者随机分为传统针刺组（TAG）、对照针刺组（CAG）和偏头痛组（MG）。针刺外关、阳陵泉、风池穴治疗。CAG组在头围、偏里、足三里穴治疗。MG没有接受任何治疗。正电子发射断层扫描与计算机断层扫描（PET-CT）被用来测试大脑激活的TAG和CAG与MG之间的差异，respectively.ResultsTraditional Acupuncture treatment is more effective for pain reduction than control acupuncture treatment. TAG在中颞叶皮质（MTC）、眶额皮质（OFC）、额中回、角回、扣带回后皮质（PCC）、楔前叶和中扣带回皮质（MCC）的脑代谢高于MG。与MG相比，TAG的海马旁、海马、梭状回、中央后回和小脑的代谢减少。在CAG中，代谢增加与MG相比，在MTC，颞上回，缘上回，MCC，而代谢减少在小脑.ConclusionsAcupuncture刺激不同点上类似的身体区域在偏头痛患者减少疼痛，并诱导不同水平的脑葡萄糖代谢疼痛相关的脑区。这些发现可能支持偏头痛治疗相关穴位的功能特异性。试验注册我们的临床试验注册号为：ChiCTR-TRC-11001813，方案和入选标准已经注册为ChiCTR-TRC-11001813。
BackgroundIn the field of acupuncture research, the topic of acupoint specificity has received increasing attention, but no unified conclusion has been reached on whether or not acupoint specificity exists. Furthermore, the majority of previous acupuncture neuroimaging studies have been performed using healthy subjects. In this study, patients with migraine were used to investigate acupoint specificity.MethodsThirty patients with migraine were enrolled and randomized into three groups: Traditional Acupuncture Group (TAG), Control Acupuncture Group (CAG), and Migraine Group (MG). The TAG was treated by acupuncture stimulation at Waiguan (TE5), Yang Lingquan (GB34), and Fengchi (GB20). The CAG was treated at Touwei (ST8), Pianli (LI6), and Zusanli (ST36). The MG received no treatment. Positron emission tomography with computed tomography (PET-CT) was used to test for differences in brain activation between the TAG and CAG versus MG, respectively.ResultsTraditional acupuncture treatment was more effective for pain reduction than control acupuncture treatment. The TAG showed higher brain metabolism than the MG in the middle temporal cortex (MTC), orbital frontal cortex (OFC), insula, middle frontal gyrus, angular gyrus, post-cingulate cortex (PCC), the precuneus, and the middle cingulate cortex (MCC). Metabolism decreased in the parahippocampus, hippocampus, fusiform gyrus, postcentral gyrus, and cerebellum in the TAG compared with the MG. In the CAG, metabolism increased compared with the MG in the MTC, supratemporal gyrus, supramarginal gyrus, and MCC, whereas metabolism decreased in the cerebellum.ConclusionsAcupuncture stimulation of different points on similar body regions in migraine patients reduced pain and induced different levels of cerebral glucose metabolism in pain-related brain regions. These findings may support the functional specificity of migraine- treatment-related acupoint.Trial registrationThe number of our clinical trial registration is: ChiCTR-TRC-11001813, and the protocol and inclusion criteria have already been registered as ChiCTR-TRC-11001813.
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影响因子：
2.2
作者：
Huang, Yong;Jiang, Xuemei;Wik, Gustav
通讯作者：
Wik, Gustav
DOI：
10.1073/pnas.95.5.2670
发表时间：
1998-03-03
影响因子：
11.1
作者：
Cho, ZH;Chung, SC;Min, BI
通讯作者：
Min, BI
影响因子：
5.7
作者：
Maenaka, Toshihiro;Tano, Kaori;Ishida, Torao
通讯作者：
Ishida, Torao
DOI：
10.3758/cabn.10.1.94
发表时间：
2010-03
期刊：
Cognitive, affective & behavioral neuroscience
影响因子：
--
作者：
Pereira MG;de Oliveira L;Erthal FS;Joffily M;Mocaiber IF;Volchan E;Pessoa L
通讯作者：
Pessoa L
影响因子：
5
作者：
Li Ying;Liang Fanrong;Zou Ran
通讯作者：
Zou Ran