Prospective Validation of Intra- and Interobserver Reproducibility of a New Point Shear Wave Elastographic Technique for Assessing Liver Stiffness in Patients with Chronic Liver Disease.
Prospective Validation of Intra- and Interobserver Reproducibility of a New Point Shear Wave Elastographic Technique for Assessing Liver Stiffness in Patients with Chronic Liver Disease.
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DOI：
10.3348/kjr.2017.18.6.926
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发表时间：
2017-11
影响因子：
4.8
通讯作者：
Han JK
中科院分区：
文献类型：
--
作者：
Ahn SJ;Lee JM;Chang W;Lee SM;Kang HJ;Yang H;Yoon JH;Park SJ;Han JK
评价一种新的点剪切波弹性成像技术(PSWE、S-Searwave、Samsung Medison)在观察者内和观察者间的重复性，并比较其与已建立的PSWE技术(虚拟触摸量化，VTQ)在评估肝脏僵硬(LS)方面的准确性。33名患者参加了这项机构审查委员会批准的前瞻性研究。在同一会议期间，分别在Acuson S2000系统(西门子Healthineer)和S-ShearWave系统(三星Medison)上用VTQ测量LS值，然后再进行两次S-Searwave会话，以8小时为间隔进行观察者间和观察者内变化。比较两种pSWE技术测量的技术成功率和可靠性。组内相关系数(ICCs)决定了S剪切波在观察者内和观察者间的重复性。用两种方法测量LS值。以瞬时弹性成像的LS值为参考标准，采用受试者工作特征曲线分析和Obuchowski测量，评价其对重度纤维化(F≥3)和肝硬变(F=4)的诊断性能。VTQ(100%，33/33)和S-剪波(96.9%，32/33)技术在技术SR(p=0.63)和LS测量的可靠性(93.9%，30/32)方面无显著差异(p=0.61)。使用S-剪切波技术测量LS的观察者间和观察者内的一致性很好(ICC分别为0.98和0.99)。两种pSWE技术的LS值差异无统计学意义，具有良好的相关性(r=0.78)。对于F-≥3和F=4，室性心动过速与S-剪波的诊断准确率相当，受试者工作特征曲线下面积分别为0.87(95%可信区间0.70~0.96)、0.89(95%可信区间0.74~0.97)，S-剪波分别为0.84(95%可信区间0.67~0.94)、0.94(95%可信区间0.80~0.99)。奥布霍夫斯基指标对于S-剪波和VTQ也是同样高的(0.94vs.0.95)。S-剪切波在检测LS方面表现出与VTQ相当的良好的观察者间和观察者内的一致性和诊断效果。
To assess intra- and inter-observer reproducibility of a new point shear wave elastography technique (pSWE, S-Shearwave, Samsung Medison) and compare its accuracy in assessing liver stiffness (LS) with an established pSWE technique (Virtual Touch Quantification, VTQ). Thirty-three patients were enrolled in this Institutional Review Board-approved prospective study. LS values were measured by VTQ on an Acuson S2000 system (Siemens Healthineer) and S-Shearwave on an RS-80A (Samsung Medison) in the same session, followed by two further S-Shearwave sessions for inter- and intra-observer variation at 8-hour intervals. The technical success rate (SR) and reliability of the measurements of both pSWE techniques were compared. The intra- and inter-observer reproducibility of S-Shearwave was determined by intraclass correlation coefficients (ICCs). LS values were measured by both methods of pSWE. The diagnostic performance in severe fibrosis (F ≥ 3) and cirrhosis (F = 4) was evaluated using the receiver operating characteristics curve analysis and the Obuchowski measure with the LS values of transient elastography as the referenced standard. The VTQ (100%, 33/33) and S-Shearwave (96.9%, 32/33) techniques did not display a significant difference in technical SR (p = 0.63) or reliability of LS measurements (96.9%, 32/33; 93.9%, 30/32, respectively, p = 0.61). The inter- and intra-observer agreement for LS measurements using the S-Shearwave technique was excellent (ICC = 0.98 and 0.99, respectively). The mean LS values of both pSWE techniques were not significantly different and exhibited a good correlation (r = 0.78). To detect F ≥ 3 and F = 4, VTQ and S-Shearwave showed comparable diagnostic accuracy as indicated by the following outcomes: areas under receiver operating characteristics curve (AUROC) = 0.87 (95% confidence intervals [CI] 0.70–0.96), 0.89 for VTQ (95% CI 0.74–0.97), respectively; and AUROC = 0.84 (95% CI 0.67–0.94), 0.94 (95% CI 0.80–0.99) for S-Shearwave (p > 0.48), respectively. The Obuchowski measures were similarly high for S-Shearwave and VTQ (0.94 vs. 0.95). S-Shearwave shows excellent inter- and intra-observer agreement and diagnostic effectiveness comparable to VTQ in detecting LS.
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影响因子：
1.7
作者：
Bota, Simona;Sporea, Ioan;Gradinaru-Tascau, Oana
通讯作者：
Gradinaru-Tascau, Oana
影响因子：
2.3
作者：
Ferraioli, Giovanna;Parekh, Parth;Filice, Carlo
通讯作者：
Filice, Carlo
影响因子：
2.9
作者：
Ferraioli, Giovanna;Filice, Carlo;Kudo, Masatoshi
通讯作者：
Kudo, Masatoshi
影响因子：
19.7
作者：
HANLEY, JA;MCNEIL, BJ
通讯作者：
MCNEIL, BJ
影响因子：
3.1
作者：
Hollerieth, Katharina;Gassmann, Bernhard;Stock, Konrad Friedrich
通讯作者：
Stock, Konrad Friedrich