Subgroup effects in a randomised trial of different types and doses of exercise during breast cancer chemotherapy.
Subgroup effects in a randomised trial of different types and doses of exercise during breast cancer chemotherapy.
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DOI：
10.1038/bjc.2014.466
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发表时间：
2014-10-28
影响因子：
8.8
通讯作者：
Segal, R. J.
中科院分区：
文献类型：
--
作者：
Courneya, K. S.;McKenzie, D. C.;Mackey, J. R.;Gelmon, K.;Friedenreich, C. M.;Yasui, Y.;Reid, R. D.;Vallerand, J. R.;Adams, S. C.;Proulx, C.;Dolan, L. B.;Wooding, E.;Segal, R. J.
关键词：
有氧运动和阻力运动联合试验测试了接受化疗的乳腺癌患者的不同类型和剂量的运动。在这里，我们探索运动训练反应的潜在主持人。将开始化疗的乳腺癌患者随机分为3组，每周3次，在监督下进行标准剂量25~30 m in的有氧运动，50~60 m in的大剂量有氧运动，或50~60 m in的联合有氧和阻力运动。结果是患者报告的症状和与健康相关的健康状况。主持人是基线人口统计、锻炼/健康和癌症变量。体重指数调节了运动干预对躯体疼痛(P=0.038)、内分泌症状(P=0.029)、紫杉烷/神经病症状(P=0.013)、有氧健身(P=0.041)、肌肉力量(P=0.007)和脂肪质量(P=0.005)的影响。一般来说，健康的体重患者比超重/肥胖患者对高剂量运动干预的反应更好。绝经状态、年龄和基线健康状况对患者报告的症状的影响有所缓和。绝经前、更年轻、更健康的患者从高剂量运动干预中获得了更大的好处。健康的体重、更健康的身体和接受化疗的绝经前/年轻的乳腺癌患者更有可能从更高剂量的运动干预中受益。
The Combined Aerobic and Resistance Exercise Trial tested different types and doses of exercise in breast cancer patients receiving chemotherapy. Here, we explore potential moderators of the exercise training responses. Breast cancer patients initiating chemotherapy (N=301) were randomly assigned to three times a week, supervised exercise of a standard dose of 25–30 min of aerobic exercise, a higher dose of 50–60 min of aerobic exercise, or a higher dose of 50–60 min of combined aerobic and resistance exercise. Outcomes were patient-reported symptoms and health-related fitness. Moderators were baseline demographic, exercise/fitness, and cancer variables. Body mass index moderated the effects of the exercise interventions on bodily pain (P for interaction=0.038), endocrine symptoms (P for interaction=0.029), taxane/neuropathy symptoms (P for interaction=0.013), aerobic fitness (P for interaction=0.041), muscular strength (P for interaction=0.007), and fat mass (P for interaction=0.005). In general, healthy weight patients responded better to the higher-dose exercise interventions than overweight/obese patients. Menopausal status, age, and baseline fitness moderated the effects on patient-reported symptoms. Premenopausal, younger, and fitter patients achieved greater benefits from the higher-dose exercise interventions. Healthy weight, fitter, and premenopausal/younger breast cancer patients receiving chemotherapy are more likely to benefit from higher-dose exercise interventions.
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影响因子：
3.1
作者：
Alberga, Angela S.;Segal, Roanne J.;Kenny, Glen P.
通讯作者：
Kenny, Glen P.
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影响因子：
3.8
作者：
Courneya, Kerry S.;Sellar, Christopher M.;Reiman, Tony
通讯作者：
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