Dysplastic nevi in association with multiple primary melanoma.
Dysplastic nevi in association with multiple primary melanoma.
复制标题
发育不良痣与多发性原发性黑色素瘤有关。
作者：
L. Titus;P. Duray;M. Ernstoff;R. Barnhill;P. Horn;J. Kirkwood
Risk factors for multiple primary cutaneous melanoma were evaluated in a case-control study. Eight cases of multiple primary melanoma were matched on sex, age, and education to 24 first primary melanoma controls. Risk factors examined in the analysis included pigmentary characteristics, history of sun exposure, and nevi. The importance of histologically dysplastic nevi (DN) and clinically atypical nevi was of particular interest. Single-factor conditional logistic regression analysis showed that first primary melanoma patients with histological DN are at increased risk for a second primary (odds ratio, 6.2; 95% confidence interval, 1.2-33.4). Patients with two or more clinically atypical nevi also have elevated risk for a second primary (odds ratio, 8.8; 95% confidence interval, 1.0-80.7). Two-factor logistic models were used to evaluate the effect of histological DN while controlling singly for all other variables as potential confounders. Odds ratios for the association of histological DN varied from 6.1 to 10.4 when adjusting singly for pigmentary and sun exposure variables. In the two-factor model that included histological and clinical DN, both variables retained marginally significant statistical association with multiple primary melanoma. These results suggest that DN is a marker of increased risk for multiple primary melanoma and suggest that melanoma patients with evidence of DN should be followed closely for the development of additional primaries.
发育不良痣综合征：我们的定义。
DOI：
10.1097/00000372-198210000-00014
发表时间：
1982
期刊：
The American Journal of dermatopathology
影响因子：
--
作者：
Elder,DE;Green,MH;Guerry4th,D;Kraemer,KH;ClarkJr,WH
通讯作者：
ClarkJr,WH
患有发育异常痣的黑色素瘤易发家庭患恶性黑色素瘤的风险较高。
影响因子：
39.2
作者：
Greene,MH;ClarkJr,WH;Tucker,MA;Kraemer,KH;Elder,DE;Fraser,MC
通讯作者：
Fraser,MC
黑色素瘤患者和比较对象中临床非典型（发育不良）痣的人口统计学研究。
影响因子：
11.2
作者：
Nordlund,JJ;Kirkwood,J;Forget,BM;Scheibner,A;Albert,DM;Lerner,E;Milton,GW
通讯作者：
Milton,GW