Autoantibodies to endostatin in patients with breast cancer: correlation to endostatin levels and clinical outcome.
Autoantibodies to endostatin in patients with breast cancer: correlation to endostatin levels and clinical outcome.
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DOI：
10.1038/sj.bjc.6603037
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发表时间：
2006-04-10
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
针对癌细胞过度表达的自身抗原的循环自身抗体在癌症患者中很常见。由于在新血管生成过程中表达特定蛋白质，因此肿瘤血管的特定抗原可能会发生类似的现象。切割内皮抑制素的胶原XVIII在肿瘤相关血管的血管周围基底膜中高度表达，并且已经报道了癌症患者中的内皮抑制素自身抗体。本研究分析了乳腺癌患者血清中天然存在的内皮抑素自身抗体的发生率及其与内皮抑素血清水平和患者临床结局的关系。使用了来自36名局部乳腺癌患者和59名具有完整记录的转移性乳腺癌病史的患者的血清样品。检测血清样品对纯化的重组人内皮抑素的免疫反应性，并通过免疫测定法测定内皮抑素水平。我们可以检测到抗内皮抑素抗体在66%的局部疾病患者和42%的转移性疾病患者的血清中（P=0.03）。内皮抑制素抗体的存在和循环内皮抑制素水平之间没有相关性。内皮抑素自身抗体的检测与转移性乳腺癌患者的预后较好相关（中位生存时间：20 vs 8个月，P=0.03），血清内皮抑素水平低的患者也是如此（中位生存时间：20 vs 9个月，P=0.007）。这些结果表明，乳腺癌患者中可以发生针对内皮抑素的天然免疫反应。这可能具有重要的治疗意义，内皮抑素治疗，并提出了一个问题，这种体液反应对内皮抑素在肿瘤过程中可能发挥的作用。
Circulating autoantibodies to self-antigens overexpressed by cancer cells are common in cancer patients. As specific proteins are expressed during neoangiogenesis, a similar phenomenon might occur with particular antigens of tumour vessels. Collagen XVIII, from which endostatin is cleaved, is highly expressed in the perivascular basement membrane of tumour-associated blood vessels and autoantibodies to endostatin have been reported in cancer patients. The present study analyses the incidence of naturally occurring autoantibodies to endostatin in the sera of breast cancer patients and their relation to endostatin serum levels and patient clinical outcome. Serum samples from 36 patients with localised breast cancer and 59 patients with a fully documented history of metastatic breast cancer were used. The immunoreactivity of serum samples was tested against purified recombinant human endostatin and endostatin levels were determined by immunoassay. We could detect anti-endostatin antibodies in the sera of 66% of the patients with localised disease and 42% of the patients with metastatic disease (P=0.03). There was no correlation between the presence of antibodies to endostatin and circulating levels of endostatin. The detection of autoantibodies to endostatin was associated with better prognosis in metastatic breast cancer patients (median survival time: 20 vs 8 months, P=0.03), as was the presence of low levels of serum endostatin (median survival time: 20 vs 9 months, P=0.007). These results show that a natural immune reaction against endostatin can occur in breast cancer patients. This could have important therapeutic implications with regard to endostatin therapy and raises the question of a possible role of this humoral reaction against endostatin in the neoplastic process.
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胶原蛋白型XVIII/内抑素在原发性和转移性结直肠癌和卵巢癌中差异表达。
影响因子：
8.8
作者：
Guenther, U;Herbst, H;Bauer, M;Isbert, C;Buhr, H J;Riecken, E O;Schuppan, D
通讯作者：
Schuppan, D
DOI：
10.1073/pnas.92.19.8763
发表时间：
1995-09-12
影响因子：
11.1
作者：
MURAGAKI, Y;TIMMONS, S;OLSEN, BR
通讯作者：
OLSEN, BR
影响因子：
45.3
作者：
Thomas, JP;Arzoomanian, RZ;Wilding, G
通讯作者：
Wilding, G
影响因子：
15.9
作者：
BROOKS, PC;STROMBLAD, S;CHERESH, DA
通讯作者：
CHERESH, DA
影响因子：
6.2
作者：
Feldman, AL;Alexander, HR;Libutti, SK
通讯作者：
Libutti, SK