Interleukin 1β inhibition contributes to the antinociceptive effects of voluntary exercise on ischemia/reperfusion-induced hypersensitivity.
Interleukin 1β inhibition contributes to the antinociceptive effects of voluntary exercise on ischemia/reperfusion-induced hypersensitivity.
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DOI：
10.1097/j.pain.0000000000001094
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发表时间：
2018-03
期刊：
影响因子：
7.4
通讯作者：
Jankowski MP
中科院分区：
文献类型：
--
作者：
Ross JL;Queme LF;Lamb JE;Green KJ;Ford ZK;Jankowski MP
外周循环问题越来越多地被认为是许多情况下肌肉骨骼疼痛的根本原因，包括镰状细胞性贫血和外周血管疾病。我们以前已经表明，在我们的模型中的短暂缺血和再灌注损伤（I/R）的前肢，个别组III和IV肌肉传入显示改变化学敏感性和机械阈值1天后损伤。功能改变对应于诱发和自发性疼痛相关行为的增加，以及肌肉力量和自主活动的减少，所有这些行为都反映了缺血性肌痛的临床症状。这些行为和生理变化似乎部分源于受损肌肉中白细胞介素1β（IL 1 β）在DRG内上调的白细胞介素1受体（IL 1 r 1）的作用。在这里，我们描述了在I/R之前两天的自愿轮跑阻断了损伤诱导的IL 1 β增强和随后的缺血性肌痛样行为的发展。此外，预先2d运动对I/R诱发的疼痛相关行为增加的保护作用也被I/R期间全身注射IL 1受体拮抗剂（IL 1 RA）所证实。IL 1 RA治疗还防止了I/R诱导的个体初级肌肉传入的机械和化学敏感性的变化。总之，这些数据加强了短暂缺血和再灌注损伤通过增加肌肉中的IL 1 β刺激缺血性肌痛发展而使III和IV组肌肉传入敏感的证据。因此，靶向IL 1 β可能是这种隐性肌肉疼痛的有效治疗策略。
Issues of peripheral circulation have been increasingly suggested as an underlying cause of musculoskeletal pain in many conditions, including sickle cell anemia and peripheral vascular disease. We have previously shown in our model of transient ischemia and reperfusion injury (I/R) of the forelimb that individual group III and IV muscle afferents display altered chemosensitivity and mechanical thresholds 1 d following injury. Functional alterations corresponded to increased evoked and spontaneous pain-related behaviors and decreased muscle strength and voluntary activity—all actions that echo clinical symptoms of ischemic myalgia. These behavioral and physiological changes appeared to originate in part from the action of increased interleukin 1β (IL1β) in the injured muscles at its upregulated interleukin 1 receptor (IL1r1) within the DRGs. Here we describe that two days of voluntary wheel running prior to I/R blocks both injury-induced IL1β enhancement and the subsequent development of ischemic myalgia-like behaviors. Furthermore, the protective effects of 2d prior exercise on the I/R-evoked increases in pain-related behaviors were also paralleled with systemic injection of the IL1 receptor antagonist (IL1RA) during I/R. IL1RA treatment additionally prevented the I/R-induced changes in mechanical and chemical sensitivity of individual primary muscle afferents. Altogether, these data strengthen the evidence that transient ischemia and reperfusion injury sensitizes group III and IV muscle afferents via increased IL1β in the muscles to stimulate ischemic myalgia development. Targeting IL1β may therefore be an effective treatment strategy for this insidious type of muscle pain.
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DOI：
10.1016/j.berh.2015.04.022
发表时间：
2015-02
期刊：
Best practice & research. Clinical rheumatology
影响因子：
--
作者：
Ambrose KR;Golightly YM
通讯作者：
Golightly YM
影响因子：
--
作者：
Jack, Kirsten;McLean, Sionnadh Mairi;Moffett, Jennifer Klaber;Gardiner, Eric
通讯作者：
Gardiner, Eric
影响因子：
5.7
作者：
Chen, Yu-Wen;Li, Yung-Tsung;Hung, Ching-Hsia
通讯作者：
Hung, Ching-Hsia
影响因子：
25
作者：
Immke, DC;McCleskey, EW
通讯作者：
McCleskey, EW
DOI：
10.1016/j.berh.2015.04.024
发表时间：
2015-02-01
影响因子：
5.2
作者：
Clauw, Daniel J.
通讯作者：
Clauw, Daniel J.