Time-dependent effects of starvation on serum, pituitary and hypothalamic leptin levels in rats.
Time-dependent effects of starvation on serum, pituitary and hypothalamic leptin levels in rats.
复制标题
饥饿对大鼠血清、垂体和下丘脑瘦素水平的时间依赖性影响。
作者：
P. Vujovic;I. Lakić;Danijela Laketa;N. Jasnić;S. Djurasevic;G. Cvijić;J. Djordjevic
瘦素由白色脂肪组织和其他类型的细胞产生，并参与短期和长期的食欲控制。本文研究了饥饿对72 h内血清、垂体和下丘脑瘦素水平的影响。每个饥饿组与自由进食组动物同时处死。通过检测血糖、游离脂肪酸、尿素和皮质酮水平来监测离散饥饿反应阶段的进展。饥饿引起皮质酮和游离脂肪酸水平的双相增加，尿素和葡萄糖水平显着但短暂的下降。饥饿也取消了血清和下丘脑和垂体组织中瘦素浓度变化的昼夜节律。仅6 h饥饿期就足以将血清瘦素锁定在较低水平，而在整个研究期间，下丘脑需要12 h才能沉默瘦素的产生/分泌。与此相反，瘦素生产的垂体组织饥饿动物需要24小时达到最低，然后完全恢复饥饿期结束。这些结果表明瘦素释放的组织特异性模式，并表明，本地产生的瘦素可以激活其受体在垂体细胞独立的血清水平的这种激素。
Leptin is produced by white adipose tissue and other cell types and is involved in both short- and long-term appetite control. Here we studied effects of starvation on serum, pituitary and hypothalamic levels of leptin during 72 h period. Each of the starved groups was sacrificed simultaneously with the group of ad libitum fed animals. The progression of the discrete starvation response phases was monitored by testing the blood glucose, free fatty acid, urea and corticosterone levels. Starvation caused biphasic increase in corticosterone and free fatty acid levels, and significant but transient decrease in urea and glucose levels. Starvation also abolished diurnal rhythm of changes in leptin concentrations in serum and hypothalamic and pituitary tissues. Only 6 h starving period was sufficient to lock serum leptin at low levels, whereas 12 h were needed to silence leptin production/secretion in hypothalamus for the whole examined period. In contrast, leptin production by pituitary tissues of starved animals required 24 h to reach minimum, followed by full recovery by the end of starvation period. These results indicate the tissue specific pattern of leptin release and suggest that the locally produced leptin could activate its receptor in pituitary cells independently of serum levels of this hormone.
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15.9
作者：
Sinha, MK;Ohannesian, JP;Caro, JF
通讯作者：
Caro, JF