Functional Imaging of Cone Photoreceptors

Functional Imaging of Cone Photoreceptors
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视锥细胞感光器的功能成像

DOI:
10.1007/978-3-319-44978-4_3
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发表时间:
2016
期刊:
影响因子:
--
通讯作者:
Harmening WM
Harmening WM
中科院分区:
--
文献类型:
--
作者:
Sincich LC;Sabesan R;Tuten WS;Roorda A;Harmening WM

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颜色遍布我们的视觉感官世界,但我们对颜色感知的神经基础的理解,从视网膜开始,通过多个皮层区域来维护视觉,仍然是不完整的。作为人类和灵长类动物三色视觉的细胞入口点,L、M和S锥光感受器已经以各种方式进行了研究,以揭示它们的相对数量、空间排列和解剖学连接。我们回顾了这些物种的工作,映射锥镶嵌直接连接到功能特性,如视网膜中的单神经元反应和颜色感知锥靶向微刺激所产生的。限制获得单锥光感受器的功能研究的技术问题也被考虑。
Color pervades our visual sensory world, yet our understanding of the neural basis of color perception, starting with the retina and on through the multiple cortical areas that subserve vision, is still incomplete. The L, M, and S cone photoreceptors, being the cellular entry point for trichromatic vision in humans and primates, have been studied in a variety of ways to reveal their relative numbers, their spatial arrangement, and their anatomical connectivity. We review work in these species that has linked mapped cone mosaics directly to functional properties such as single neuron responses in the retina and color percepts arising from cone-targeted microstimulation. Technical issues that constrain access to single cone photoreceptors for functional studies are also considered.
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