Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial.
Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial.
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DOI：
10.1111/dom.13514
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Martínez-González MA
中科院分区：
文献类型：
--
作者：
Yu E;Ruiz-Canela M;Razquin C;Guasch-Ferré M;Toledo E;Wang DD;Papandreou C;Dennis C;Clish C;Liang L;Bullo M;Corella D;Fitó M;Gutiérrez-Bedmar M;Lapetra J;Estruch R;Ros E;Cofán M;Arós F;Romaguera D;Serra-Majem L;Sorlí JV;Salas-Salvadó J;Hu FB;Martínez-González MA
精氨酸代谢物与2型糖尿病（T2D）发病率之间的关系尚不清楚。我们在PREDIMED试验中采用病例队列设计，在892名个体（251例）中检测6种血浆代谢物（精氨酸、瓜氨酸、鸟氨酸、不对称二甲基精氨酸[ADMA]、对称二甲基精氨酸[SDMA]和n -单甲基-l-精氨酸[NMMA]）与T2D和胰岛素抵抗的关系。采用具有稳健方差的加权Cox模型。1年内精氨酸（校正HR / SD = 0.68, 95% CI = 0.49, 0.95; Q4 vs. Q1 = 0.46, 95% CI = 0.21, 1.04, p-trend = 0.02）和精氨酸/ADMA比值（校正HR / SD = 0.73, 95% CI = 0.51, 1.04; Q4 vs. Q1 = 0.52, 95% CI = 0.22, 1.25, p-trend = 0.04）的变化与T2D风险降低相关。瓜氨酸和鸟氨酸呈阳性变化，SDMA和精氨酸/（鸟氨酸+瓜氨酸）呈阴性变化与1年HOMA-IR同时发生变化相关。与地中海饮食组相比，低脂饮食组的个体在1年NMMA变化中发生T2D的风险更高（p-相互作用= 0.02）。精氨酸的生物利用度在T2D病理生理中很重要。
The associations between arginine-based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case-cohort design nested within the PREDIMED trial to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA], and N-monomethyl-l-arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. 1-year changes in arginine (Adjusted HR per SD = 0.68, 95% CI = 0.49, 0.95; Q4 vs. Q1 = 0.46, 95% CI = 0.21, 1.04, p-trend = 0.02) and arginine/ADMA ratio (Adjusted HR per SD = 0.73, 95% CI = 0.51, 1.04; Q4 vs. Q1 = 0.52, 95% CI = 0.22, 1.25, p-trend = 0.04) were associated with lower risk of T2D. Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine+citrulline) were associated with concurrent 1-year changes in HOMA-IR. Individuals in the low fat diet group experienced higher risk of T2D for 1-year changes in NMMA than individuals in Mediterranean diet groups (p-interaction = 0.02). Arginine bioavailability is important in T2D pathophysiology.
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影响因子：
4.6
作者：
Yamakado M;Nagao K;Imaizumi A;Tani M;Toda A;Tanaka T;Jinzu H;Miyano H;Yamamoto H;Daimon T;Horimoto K;Ishizaka Y
通讯作者：
Ishizaka Y
DOI：
10.1111/j.1463-1326.2010.01267.x
发表时间：
2010-10
期刊：
Diabetes, obesity & metabolism
影响因子：
--
作者：
Knott AB;Bossy-Wetzel E
通讯作者：
Bossy-Wetzel E
DOI：
10.1900/rds.2010.7.15
发表时间：
2010-01-01
期刊：
The review of diabetic studies : RDS
影响因子：
--
作者：
Pitocco, Dario;Zaccardi, Francesco;Ghirlanda, Giovanni
通讯作者：
Ghirlanda, Giovanni
影响因子：
16.2
作者：
Piatti, P;Monti, LD;Alberti, KGMM
通讯作者：
Alberti, KGMM
影响因子：
24
作者：
Tang, W. H. Wilson;Wang, Zeneng;Cho, Leslie;Brennan, Danielle M.;Hazen, Stanley L.
通讯作者：
Hazen, Stanley L.