Drug induced phospholipidosis: an acquired lysosomal storage disorder.
Drug induced phospholipidosis: an acquired lysosomal storage disorder.
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DOI：
10.1016/j.bbalip.2012.08.013
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Abe A
中科院分区：
文献类型：
--
作者：
Shayman JA;Abe A
There is a strong association between lysosome enzyme deficiencies and monogenic disorders resulting in lysosomal storage disease. Of the more than 75 characterized lysosomal proteins, two thirds are directly linked to inherited diseases of metabolism. Only one lysosomal storage disease, Niemann-Pick disease, is associated with impaired phospholipid metabolism. However, other phospholipases are found in the lysosome but remain poorly characterized. A recent exception is lysosomal phospholipase A2 (group XV phospholipase A2). Although no inherited disorder of lysosomal phospholipid metabolism has yet been associated with a loss of function of this lipase, this enzyme may be a target for an acquired form of lysosomal storage, drug induced phospholipidosis.
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