MicroRNAs and cell fate in cortical and retinal development.
MicroRNAs and cell fate in cortical and retinal development.
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DOI：
10.3389/fncel.2013.00141
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发表时间：
2013-09-03
影响因子：
5.3
通讯作者：
Cremisi F
中科院分区：
文献类型：
--
作者：
Cremisi F
MicroRNAs(MiRNAs)参与神经发生、神经分化和神经元可塑性的关键步骤。在这里，我们回顾了表明miRNAs可能调节大脑皮层和神经视网膜的组织发生的实验证据。皮质和视网膜早期祖细胞都是多能的，也就是说，它们可以在一个谱系中分别产生不同类型的皮质或视网膜细胞。在皮质和视网膜发育中，细胞命运转录因子的精确激活时间导致了不同类型神经元的生成刻板印象。新的证据表明，miRNAs可能在调节这种神经元分化的时间程序中发挥重要作用。皮质和视网膜的神经元亚型显示出不同的miRNA签名，这意味着miRNA编码可以用于指定不同类型的神经元。干扰全球miRNA活性会改变不同类型神经元产生的比例。事实上，有一些细胞命运基因在翻译水平上受到调控，无论是在视网膜发生过程中还是在皮质发生过程中。提出并讨论了一个模型，描述了miRNAs如何协调不同神经元的类型和出生。词汇表。·谱系：单个祖细胞在时间上有序的后代。·规范：细胞能够并偏向某一特定命运的(可逆)过程。·承诺：细胞命运完全被决定，不再受外部信号影响的过程。·潜能：祖细胞最终能产生的全部细胞。·多能性：产生一种以上细胞类型的能力。·祖细胞：与干细胞不同的是，分裂细胞不能无限增殖。·Antago-miR：修饰的反义寡核苷酸，可阻断miRNA的活性。·异时神经元：在不适当的发育时间产生的神经元类型。·神经元出生日期：神经元细胞最后一次有丝分裂的时间。
MicroRNAs (miRNAs) are involved in crucial steps of neurogenesis, neural differentiation, and neuronal plasticity. Here we review experimental evidence suggesting that miRNAs may regulate the histogenesis of the cerebral cortex and neural retina. Both cortical and retinal early progenitor cells are multipotent, that is, they can generate different types of cortical or retinal cells, respectively, in one lineage. In both cortical and retinal development, the precise timing of activation of cell fate transcription factors results in a stereotyped schedule of generation of the different types of neurons. Emerging evidence indicates that miRNAs may play an important role in regulating such temporal programing of neuronal differentiation. Neuronal subtypes of the cortex and retina exhibit distinct miRNA signatures, implying that miRNA codes may be used to specify different types of neurons. Interfering with global miRNA activity changes the ratio of the different types of neurons produced. In fact, there are examples of cell fate genes that are regulated at the translational level, both in retinogenesis and in corticogenesis. A model depicting how miRNAs might orchestrate both the type and the birth of different neurons is presented and discussed. Glossary. • Lineage: the temporally ordered cell progeny of an individual progenitor cell. • Specification: the (reversible) process by which a cell becomes capable of, and biased toward, a particular fate. • Commitment: the process by which cell fate is fully determined and can no longer be affected by external cues. • Potency: the entire complement of cells that a progenitor can ultimately produce. • Multipotency: the ability to give rise to more than one cell type. • Progenitor: a dividing cell that, in contrast to a stem cell, cannot proliferate indefinitely. • Antago-miR: modified antisense oligonucleotide that blocks the activity of a miRNA. • Heterochronic neuron: type of neurons that is generated at inappropriate times of development. • Neuron birth date: the time of the last mitosis of a neuronal cell.
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影响因子：
9.8
作者：
Decembrini S;Andreazzoli M;Vignali R;Barsacchi G;Cremisi F
通讯作者：
Cremisi F
影响因子：
2.5
作者：
Kawase-Koga, Yoko;Otaegi, Gaizka;Sun, Tao
通讯作者：
Sun, Tao
影响因子：
16.2
作者：
HOLT, CE;BERTSCH, TW;HARRIS, WA
通讯作者：
HARRIS, WA
DOI：
10.1073/pnas.0914785107
发表时间：
2010-08-31
影响因子：
11.1
作者：
Conte, Ivan;Carrella, Sabrina;Banfi, Sandro
通讯作者：
Banfi, Sandro
影响因子：
5.3
作者：
Davis, Tigwa H.;Cuellar, Trinna L.;Ullian, Erik M.
通讯作者：
Ullian, Erik M.