Relationship of epicardial fat volume to coronary plaque, severe coronary stenosis, and high-risk coronary plaque features assessed by coronary CT angiography.
Relationship of epicardial fat volume to coronary plaque, severe coronary stenosis, and high-risk coronary plaque features assessed by coronary CT angiography.
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DOI：
10.1016/j.jcct.2013.02.003
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发表时间：
2013-03
影响因子：
5.4
通讯作者：
Dey D
中科院分区：
文献类型：
--
作者：
Rajani R;Shmilovich H;Nakazato R;Nakanishi R;Otaki Y;Cheng VY;Hayes SW;Thomson LE;Friedman JD;Slomka PJ;Min JK;Berman DS;Dey D
心脏计算机断层扫描(NCT)测量的心外膜脂肪体积(EFV)与冠状动脉斑块、心肌缺血和不良心脏事件相关。本研究旨在明确EFV与冠状动脉斑块类型、严重冠状动脉狭窄和高危斑块特征(HRPF)的关系。我们回顾评估了402名无冠状动脉病史的连续患者，他们在同一天接受了心脏CT平扫(NCT)和冠状动脉CT血管成像(CTA)。使用经过验证的半自动软件在NCT上测量EFV。冠状动脉CTA评价冠状动脉斑块类型[钙化(CP)、非钙化(NCP)或部分钙化(MP)]和冠状动脉狭窄程度≥70%。对于NCP和PCP患者，评估2个高危斑块特征：低密度斑块和正性重构。共有402名患者，中位年龄为66岁(23-92岁)，其中226名(56%)为男性。慢性前列腺炎(112±55 cm3vs.89±39cm3)、慢性肺囊性肺炎(110±57cm3vs.98±45cm3)和非慢性前列腺炎(115±44cm3vs.EFV100±52cm3)患者的EFV较大。经多因素分析，在调整常规心血管危险因素后，EFV是≥70%冠状动脉狭窄(OR3.0，95%CI1.3~6.6，p=0.008)、任何高危斑块特征(OR1.7，95%CI0.9~3.4，p=0.04)和低关注度斑块(OR2.4，95%CI1.1~5.1，p=0.02)的独立预测因子，但不是正向重构的独立预测因素。CP、PCP和NCP患者的心外膜脂肪体积较大。在NCP和PCP患者中，EFV与冠状动脉严重狭窄、高危斑块特征和低密度斑块显著相关。
Associations of epicardial fat volume (EFV) measured on non-contrast cardiac computed tomography (NCT) include coronary plaque, myocardial ischemia and adverse cardiac events. This study aimed to define the relationship of EFV to coronary plaque type, severe coronary stenosis, and to the presence of high-risk plaque features (HRPFs). We retrospectively evaluated 402 consecutive patients, with no prior history of coronary artery disease, who underwent same day non-contrast cardiac computed tomography (NCT) and coronary CT angiography (CTA). EFV was measured on NCT using validated, semi-automated, software. The coronary arteries were evaluated for coronary plaque type [calcified (CP), non-calcified (NCP) or partially-calcified (MP)] and coronary stenosis severity ≥70% using coronary CTA. For patients with NCP and PCP, 2 high risk plaque features were evaluated: Low-attenuation plaque and positive remodeling. There were 402 patients with a median age of 66 years (range 23–92) of whom 226 (56%) were male. The EFV was larger in patients with CP (112 ± 55 cm3 vs. 89 ± 39 cm3), PCP (110 ± 57 cm3 vs. 98 ± 45 cm3) and NCP (115 ± 44 cm3 vs. EFV 100 ± 52 cm3. In the 192 patients with PCP or NCP, on multivariable analysis, after adjusting for conventional cardiovascular risk factors, EFV was an independent predictor of ≥70% coronary artery stenosis (OR 3.0, 95% CI 1.3–6.6, p=0.008), any high risk plaque features (OR 1.7, 95% CI 0.9–3.4, p=0.04) and low attention plaque (OR 2.4, 95% CI 1.1–5.1, p=0.02), but not of positive remodeling. Epicardial fat volume is larger in patients with CP, PCP and NCP. In patients with NCP and PCP, EFV is significantly associated with severe coronary stenosis, high risk plaque features and low attenuation plaque.
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影响因子：
5.4
作者：
Nakazato, Ryo;Shmilovich, Haim;Dey, Damini
通讯作者：
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