Role of MTA2 in human cancer.
Role of MTA2 in human cancer.
复制标题
DOI：
10.1007/s10555-014-9518-0
复制
发表时间：
2014-12
影响因子：
9.2
通讯作者：
Fuqua, Suzanne A. W.
中科院分区：
文献类型：
--
作者：
Covington, Kyle R.;Fuqua, Suzanne A. W.
转移是大多数癌症患者死亡的最终原因。虽然许多机制已经描述了原发肿瘤的生长和肿瘤起始的调节，但对转移过程知之甚少。转移需要细胞过程的动态改变，以便细胞从原发肿瘤扩散到远处。这些改变通常涉及细胞骨架和细胞-环境相互作用调节的剧烈变化。此外，这些相互作用的控制细化需要反馈到细胞核中的调节网络。MTA2是转移性肿瘤相关转录调控家族的一员，是核小体重塑和组蛋白去乙酰化复合体的核心成分。MTA2作为细胞骨架组织和转录的中心枢纽，提供细胞核和细胞骨架组织之间的联系。本章我们将重点讨论MTA2，特别是它在乳腺癌转移中的作用。
Metastasis is the ultimate cause of death for most cancer patients. While many mechanisms have been delineated for regulation of growth and tumor initiation of the primary tumor, very little is known about the process of metastasis. Metastasis requires dynamic alteration of cellular processes in order for cells to disseminate from the primary tumor to distant sites. These alterations often involve dramatic changes in the regulation of cytoskeletal and cell-environment interactions. Furthermore, controlled refinement of these interactions requires feedback to regulatory networks in the nucleus. MTA2 is a member of the metastasis tumor associated family of transcriptional regulators and is a central component of the nucleosome remodeling and histone deacetylation complex. MTA2 acts as a central hub for cytoskeletal organization and transcription and provides a link between nuclear and cytoskeletal organization. We will focus on MTA2 in this chapter, especially its role in breast cancer metastasis.
登录
查看更多内容
影响因子：
56.9
作者：
Choudhary, Chunaram;Kumar, Chanchal;Mann, Matthias
通讯作者：
Mann, Matthias
影响因子：
--
作者：
Fujita, N;Kajita, M;Wade, PA
通讯作者：
Wade, PA
影响因子：
3.8
作者：
Covington, Kyle R.;Brusco, Lauren;Barone, Ines;Tsimelzon, Anna;Selever, Jennifer;Corona-Rodriguez, Arnoldo;Brown, Powel;Kumar, Rakesh;Hilsenbeck, Susan G.;Fuqua, Suzanne A. W.
通讯作者：
Fuqua, Suzanne A. W.
影响因子：
2.9
作者：
Amano, Mutsuki;Nakayama, Masanori;Kaibuchi, Kozo
通讯作者：
Kaibuchi, Kozo
影响因子：
5.3
作者：
Carr, Heather S.;Zuo, Yan;Frost, Jeffrey A.
通讯作者：
Frost, Jeffrey A.