Deciphering a critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution.
Deciphering a critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution.
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DOI：
10.1038/s41467-023-43102-8
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发表时间：
2023-11-14
影响因子：
16.6
通讯作者：
Deng, Wenbo
中科院分区：
文献类型：
--
作者：
Liu, Meng;Ji, Mengjun;Cheng, Jianghong;Li, Yingzhe;Tian, Yingpu;Zhao, Hui;Wang, Yang;Zhu, Sijing;Zhang, Leilei;Xu, Xinmei;Feng, Gen-Sheng;Liang, Xiaohuan;Bao, Haili;Tang, Yedong;Kong, Shuangbo;Lu, Jinhua;Wang, Haibin;Lu, Zhongxian;Deng, Wenbo
女性分娩的及时开始是怀孕成功的关键决定因素。高度异质性的母体蜕膜越来越被认为是决定分娩时机的重要因素。尽管细胞类型在分娩中的特定作用，子宫上皮在蜕膜中的作用仍然知之甚少。这项研究揭示了上皮SHP 2通过COX 1和COX 2衍生的PGF 2 α在分娩启动中的关键作用，利用上皮特异性Shp 2敲除小鼠，其破坏导致延迟分娩启动、难产和胎儿死亡。此外，我们还表明，有不同类型的上皮细胞在蜕膜接近分娩在单细胞分辨率伴随着深刻的上皮重组通过增殖。同时，上皮细胞通过与基质细胞和巨噬细胞沟通来维持微环境。上皮微环境由子宫间质细胞的上皮细胞、间质细胞和巨噬细胞之间的密切相互作用维持。简而言之，这项研究提供了一个以前未被重视的作用，上皮在分娩准备和揭示了预防早产。分娩启动的机制仍然难以捉摸。在这里，作者表明，上皮是一个低估的网站分娩启动通过上皮PGF 2a由SHP 2-COX 1/COX 2调节。
The timely onset of female parturition is a critical determinant for pregnancy success. The highly heterogenous maternal decidua has been increasingly recognized as a vital factor in setting the timing of labor. Despite the cell type specific roles in parturition, the role of the uterine epithelium in the decidua remains poorly understood. This study uncovers the critical role of epithelial SHP2 in parturition initiation via COX1 and COX2 derived PGF2α leveraging epithelial specific Shp2 knockout mice, whose disruption contributes to delayed parturition initiation, dystocia and fetal deaths. Additionally, we also show that there are distinct types of epithelium in the decidua approaching parturition at single cell resolution accompanied with profound epithelium reformation via proliferation. Meanwhile, the epithelium maintains the microenvironment by communicating with stromal cells and macrophages. The epithelial microenvironment is maintained by a close interaction among epithelial, stromal and macrophage cells of uterine stromal cells. In brief, this study provides a previously unappreciated role of the epithelium in parturition preparation and sheds lights on the prevention of preterm birth. The mechanism of parturition initiation remains elusive. Here, authors show that epithelium is an underestimated site for parturition initiation via epithelial PGF2a regulated by SHP2-COX1/COX2.
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影响因子：
7.7
作者：
Garin-Shkolnik, Tali;Rudich, Assaf;Rubinstein, Menachem
通讯作者：
Rubinstein, Menachem
影响因子：
4.6
作者：
Boretto, Matteo;Cox, Benoit;Vankelecom, Hugo
通讯作者：
Vankelecom, Hugo
DOI：
10.1126/science.1233321
发表时间：
2013-03-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Fung KY;Mangan NE;Cumming H;Horvat JC;Mayall JR;Stifter SA;De Weerd N;Roisman LC;Rossjohn J;Robertson SA;Schjenken JE;Parker B;Gargett CE;Nguyen HP;Carr DJ;Hansbro PM;Hertzog PJ
通讯作者：
Hertzog PJ
影响因子：
15.9
作者：
Hirota, Yasushi;Daikoku, Takiko;Dey, Sudhansu K.
通讯作者：
Dey, Sudhansu K.
DOI：
10.1186/1477-7827-2-58
发表时间：
2004-07-20
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Hempstock, Joanne;Cindrova-Davies, Tereza;Burton, Graham J
通讯作者：
Burton, Graham J