The importance of glucocorticoids in alcohol dependence and neurotoxicity.
The importance of glucocorticoids in alcohol dependence and neurotoxicity.
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DOI：
10.1111/j.1530-0277.2010.01298.x
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Little HJ
中科院分区：
文献类型：
--
作者：
Rose AK;Shaw SG;Prendergast MA;Little HJ
下丘脑-垂体-肾上腺（HPA）功能的改变已经在酗酒者和啮齿动物中被描述过，但糖皮质激素在饮酒中的作用及其机制直到最近才得到关注。饮酒和戒酒都会提高循环糖皮质激素水平，而长期高浓度的糖皮质激素已知会对神经元功能和认知产生有害影响。这篇小型综述涵盖了糖皮质激素可能参与饮酒行为的方式，从社交饮酒到依赖，以及在戒断期间看到的酒精消费的负面后果，这可能对治疗结果产生不利影响。研究表明，长期戒酒后，脑糖皮质激素浓度增加，糖皮质激素受体占用减少。有证据表明，慢性酒精治疗后大脑中糖皮质激素水平的增加与戒酒期间的认知缺陷有关，这影响了治疗效果和生活质量。对器官型培养的研究也证明糖皮质激素在酒精依赖的神经病理后果中的重要性。
Alterations in hypothalamo-pituitary adrenal (HPA) function have been described in alcoholics and in rodents after chronic alcohol consumption but the role of glucocorticoids in alcohol consumption, and the mechanisms involved, have received little attention until recently. Both alcohol consumption and withdrawal from chronic alcohol intake raise circulating glucocorticoid levels and prolonged high concentrations of glucocorticoids are known to have detrimental effects on neuronal function and cognition. This minireview covers the ways in which glucocorticoids may be involved in drinking behavior, from social drinking to dependence, and the negative consequences of alcohol consumption seen during withdrawal which may have a detrimental effect on treatment outcome. Research shows increases in brain glucocorticoid concentrations and decreased glucocorticoid receptor occupancy during prolonged abstinence after withdrawal from chronic alcohol treatments. Evidence suggests that increased glucocorticoid levels in the brain after chronic alcohol treatment are associated with the cognitive deficits seen during abstinence which impact on treatment efficacy and quality of life. Studies on organotypic cultures also demonstrate the importance of glucocorticoids in the neuropathological consequences of alcohol dependence.
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影响因子：
2.9
作者：
DAVIDSON, MD;WILCE, P;SHANLEY, BC
通讯作者：
SHANLEY, BC
影响因子：
2.9
作者：
DAVIDSON, M;SHANLEY, B;WILCE, P
通讯作者：
WILCE, P
影响因子：
3.3
作者：
Cho, K;Little, HJ
通讯作者：
Little, HJ
DOI：
10.1111/j.1530-0277.1987.tb01311.x
发表时间：
1987-06-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
DOLINSKY, ZS;MORSE, DE;POMERLEAU, OF
通讯作者：
POMERLEAU, OF
影响因子：
3.3
作者：
Brooks, S. P.;Croft, A. P.;Little, H. J.
通讯作者：
Little, H. J.