The Correlation Between Migraine and Patent Foramen Ovale.

The Correlation Between Migraine and Patent Foramen Ovale.
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DOI:
10.3389/fneur.2020.543485
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发表时间:
2020
影响因子:
3.4
通讯作者:
Pan M
Pan M
中科院分区:
医学3区
文献类型:
--
作者:
Liu K;Wang BZ;Hao Y;Song S;Pan M

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背景:偏头痛是一种广泛存在的神经系统疾病。卵圆孔未闭(PFO)是胎儿循环的残余。多项研究表明,偏头痛在PFO患者中更常见,反之亦然。目前尚不清楚这两种情况是否存在因果关系,或者只是共存。此外,经皮闭合性PFO治疗偏头痛仍存在争议。方法:我们回顾了有关PFO与偏头痛的关系以及治疗对偏头痛发作的影响的研究。结果:简要总结了偏头痛可能的病理生理机制,详细阐述了偏头痛合并PFO的类型、频率、临床症状以及PFO合并偏头痛的临床特点。我们还讨论了关闭PFO对偏头痛发作的影响。结论:证据支持偏头痛和PFO之间的“剂量-反应”关系,尽管在患者选择方面以及在PFO闭合干预中纳入抗血小板对照组方面还需要做更多的工作,以在临床试验中发现可能的有益结果。
Background: Migraine is a widespread neurological disorder. The patent foramen ovale (PFO) is a remnant of the fetal circulation. Multiple studies suggest that migraine is more prevalent in subjects with PFO and vice versa. It is unclear if there is a causal relationship or simply a co-existence of these two conditions. Furthermore, the treatment of migraine with percutaneous closure PFO remains controversial. Methods: We reviewed studies pertaining to the relationship between PFO and migraine as well as the effects of treatments on migraine attacks. Results: We briefly summarized potential pathophysiological mechanisms of migraine, and elaborated on migraine type, frequency, and clinical symptoms of migraine with PFO and the clinical features of PFO with migraine. We also addressed the effects of PFO closure on migraine attacks. Conclusion: The evidence supports a “dose-response” relationship between migraine and PFO although more work needs to be done in terms of patient selection as well as the inclusion of an antiplatelet control group for PFO closure interventions to uncover possible beneficial results in clinical trials.
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