Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic Target.
Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic Target.
复制标题
DOI：
10.3389/fphar.2018.01280
复制
发表时间：
2018
影响因子：
5.6
通讯作者：
Bellezza I
中科院分区：
文献类型：
--
作者：
Bellezza I
黄斑变性是老年人视力丧失的主要原因之一。遗传、环境损伤和年龄相关问题是疾病发展的风险因素。所有这些危险因素都与氧化应激的诱导有关。在年轻受试者中，视网膜色素上皮细胞通过线粒体自噬消除功能障碍的线粒体以及通过Nrf2激活增加抗氧化防御来减轻活性氧的产生。视网膜吸收大量的紫外线，再加上吸烟，与衰老过程共同作用，增加了视网膜色素上皮细胞产生的活性氧的量，氧化应激在视网膜色素上皮细胞中出现。此外，在老年人中，线粒体吞噬过程和Nrf2活化都受损，从而导致视网膜细胞死亡。本综述将重点关注氧化应激对年龄相关性黄斑变性发病机制的影响，并分析已被测试为该疾病潜在治疗药物的天然和合成Nrf2激活化合物。
Age-related macular degeneration is one of the leading causes of vision loss in the elderly. Genetics, environmental insults, and age-related issues are risk factors for the development of the disease. All these risk factors are linked to the induction of oxidative stress. In young subjects retinal pigment epithelial cells mitigate reactive oxygen generation by the elimination of dysfunctional mitochondria, via mitophagy, and by increasing antioxidant defenses via Nrf2 activation. The high amount of UV light absorbed by the retina, together with cigarette smoking, cooperate with the aging process to increase the amount of reactive oxygen species generated by retinal pigment epithelium where oxidative stress arises. Moreover, in the elderly both the mitophagic process and Nrf2 activation are impaired thus causing retinal cell death. This review will focus on the impact of oxidative stress on the pathogenesis of age-related macular degeneration and analyze the natural and synthetic Nrf2-activating compounds that have been tested as potential therapeutic agents for the disease.
登录
查看更多内容
影响因子：
3.7
作者：
Fujihara, Masashi;Nagai, Norihiro;Sussan, Thomas E.;Biswal, Shyam;Handa, James T.
通讯作者：
Handa, James T.
香烟烟雾诱导的自噬损伤调节 ARPE-19 细胞中的 AMD 发病机制。
影响因子：
3.7
作者：
Govindaraju VK;Bodas M;Vij N
通讯作者：
Vij N
影响因子：
2.7
作者：
Dulull, Nabeela K.;Dias, Daniel A.;Kwa, Faith A. A.
通讯作者：
Kwa, Faith A. A.
影响因子：
6.1
作者：
Frede, Katja;Ebert, Franziska;Baldermann, Susanne
通讯作者：
Baldermann, Susanne
DOI：
10.1073/pnas.1800431115
发表时间：
2018-09-04
影响因子：
11.1
作者：
Early JO;Menon D;Wyse CA;Cervantes-Silva MP;Zaslona Z;Carroll RG;Palsson-McDermott EM;Angiari S;Ryan DG;Corcoran SE;Timmons G;Geiger SS;Fitzpatrick DJ;O'Connell D;Xavier RJ;Hokamp K;O'Neill LAJ;Curtis AM
通讯作者：
Curtis AM