Measurement of plasma atrial natriuretic peptide as an indicator of prognosis in dogs with cardiac disease.
Measurement of plasma atrial natriuretic peptide as an indicator of prognosis in dogs with cardiac disease.
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血浆心房钠尿肽的测量作为患有心脏病的狗的预后指标。
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
C. H. Van Liew
中科院分区：
文献类型：
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作者：
D. Greco;B. Biller;C. H. Van Liew
在一项为期 12 个月的研究中，通过测量基线血浆心房钠尿肽 (ANP) 浓度，对 23 只患有心力衰竭的狗进行了评估。 10 只狗被分类为患有轻度至中度心脏病（第 1 组），13 只狗被分类为患有严重心脏病（第 2 组）。第 1 组狗的平均血浆 ANP 浓度为 64 +/- 45 pg/mL，第 2 组狗的平均血浆 ANP 浓度为 328 +/- 122 pg/mL。第 1 组狗的中位生存时间（1,095 天）明显长于第 2 组狗（58 天）（P < 0.05）。与 ANP > 95 pg/mL（58 天）的狗相比，血浆 ANP < 95 pg/mL（1095 天）的狗的中位生存期显着（P < 0.05）更高。血浆 ANP 浓度是心力衰竭犬生存的潜在无创预测指标。
Twenty-three dogs with heart failure were evaluated in a 12-month study by measuring baseline plasma atrial natriuretic peptide (ANP) concentrations. Ten dogs were classified as having mild to moderate cardiac disease (group 1) and 13 dogs were classified as having severe cardiac disease (group 2). The mean plasma ANP concentration for the group 1 dogs was 64 +/- 45 pg/mL and for the group 2 dogs, 328 +/- 122 pg/mL. The median survival time (1,095 d) for group 1 dogs was significantly greater (P < 0.05) than for group 2 dogs (58 d). A significantly (P < 0.05) greater median survival was noted for dogs with plasma ANP < 95 pg/mL (1095 d) compared with those with ANP > 95 pg/mL (58 d). Plasma ANP concentrations are a potential noninvasive predictor of survival in dogs with heart failure.
通过心房扩张，从离体大鼠心房中释放 ANF、proANF 1-98 和 proANF 31-67。
DOI：
10.1152/ajpheart.1991.260.6.h1774
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
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作者：
Dietz,JR;Nazian,SJ;Vesely,DL
通讯作者：
Vesely,DL