Nonallergic rhinitis: therapeutic options
Nonallergic rhinitis: therapeutic options
复制标题
非过敏性鼻炎：治疗选择
DOI：
--
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发表时间：
2013
影响因子：
2.8
通讯作者：
J. Bernstein
中科院分区：
文献类型：
--
作者：
J. Bernstein
综述的目的本综述的目的是简要讨论非变应性鼻炎（NAR）的分类方法，目前对其免疫发病机制的理解，以科学证据为基础的治疗方案沿着为这些具有挑战性的患者选择不同的治疗方案的轶事临床经验。NAR也被称为特发性鼻炎，刺激性鼻炎和血管性鼻炎是一种异质性疾病，已被分类为许多不同的方式，但目前还没有共识的定义，这种情况下，由于其阐明机制（S）的行动。典型的患者表现为鼻塞、鼻后引流伴或不伴咳嗽，伴有一定程度的喷嚏、瘙痒和流涕。最近的研究提出了更具体的方法来表征鼻炎亚型。据推测，这种情况是由于自主神经失衡导致副交感神经过度活跃，可能是交感神经系统活动不足。我们对NAR作用机制的理解不足，严重阻碍了开发这种疾病的新疗法的进展。需要进一步的研究来了解导致这种异常反应的神经源性信号通路。在我们对NAR进行选择性治疗之前，治疗需要选择最适合患者症状需求的药物或药物组合。
Purpose of reviewThe purpose of this review is to briefly discuss methods for classifying Nonallergic rhinitis (NAR), the current understanding of its immunopathogenesis, scientific evidence-based treatment options along with anecdotal clinical experience for selecting different treatment regimens for these challenging patients. Recent findingsNAR also known as idiopathic rhinitis, irritant-induced rhinitis and vasomotor rhinitis is a heterogeneous condition that has been classified many different ways, but currently there is no consensus on definition for this condition due to its poorly elucidated mechanism(s) of action. A typical patient presents with nasal congestion, postnasal drainage with or without a cough associated with, to a lesser extent, some degree of sneezing, itching, and rhinorrhea. Recent studies have proposed more specific approaches for characterizing rhinitis subtypes. It is speculated that this condition is due to an autonomic imbalance resulting in an overactive parasympathetic and perhaps an underactive sympathetic nervous system. Our poor understanding of NAR mechanism(s) of action has significantly hindered progress in developing novel therapies for this condition. SummaryFurther investigation is required to understand the neurogenic signaling pathways that lead to this aberrant response. Until we have selective therapies for NAR, treatment requires selecting the medication or combination of medications best suited to the symptomatic needs of the patient.
影响因子：
5.8
作者：
Gees, Maarten;Owsianik, Grzegorz;Voets, Thomas
通讯作者：
Voets, Thomas
高刺激性触发负荷与低刺激性触发负担的慢性鼻炎患者的临床特征。
DOI：
10.1016/j.anai.2012.06.013
发表时间：
2012
期刊：
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
影响因子：
--
作者：
Bernstein,JonathanA;Levin,LindaS;Al-Shuik,Enas;Martin,VincentT
通讯作者：
Martin,VincentT