MicroRNAs in cardiomyocyte development.
MicroRNAs in cardiomyocyte development.
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DOI：
10.1002/wsbm.111
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发表时间：
2011-03
影响因子：
7.9
通讯作者：
Wang, Da-Zhi
中科院分区：
文献类型：
--
作者：
Malizia, Andrea P.;Wang, Da-Zhi
MicroRNAs(MiRNAs)在转录后水平负调控基因的表达，主要是通过与其靶mRNAs的3‘-非翻译区(3’-UTR)进行碱基配对。许多miRNAs以组织/器官特异性的方式表达，并与越来越多的细胞增殖、分化和组织发育事件有关。心肌表达不同的基因，编码结构蛋白和控制组织规范和分化的信号分子的子集。心肌细胞发育的转录调控已经被很好地建立起来，然而直到最近才发现miRNAs参与调控网络。MiRNAs的一个子集在心肌中特异或高表达，为了解这种肌肉类型中miRNAs如何在转录后水平控制基因表达提供了机会。MiR-1、miR-133、miR-206和miR-208被发现是肌肉特异性的，因此被称为myomiRs。在基因表达调控中，myomiRs是一个以前未被认识到的成分，这一发现为我们对心肌发育的理解增加了一个全新的复杂性层面。研究myomiRs不仅将揭示miRNA介导的调控网络在心肌细胞发育中的新的分子机制，而且将为心血管疾病的治疗干预提供新的机会。
MicroRNAs (miRNAs) negatively regulate gene expression at the post-transcriptional level, primarily by base-pairing with the 3’-untranslated region (3’-UTR) of their target mRNAs. Many miRNAs are expressed in a tissue/organ-specific manner and are associated with an increasing number of cell proliferation, differentiation and tissue development events. Cardiac muscle expresses distinct genes encoding structural proteins and a subset of signal molecules that control tissue specification and differentiation. The transcriptional regulation of cardiomyocyte development has been well established, yet only until recently has it been uncovered that miRNAs participate in the regulatory networks. A subset of miRNAs are either specifically or highly expressed in cardiac muscle, providing an opportunity to understand how gene expression is controlled by miRNAs at the post-transcriptional level in this muscle type. miR-1, miR-133, miR-206 and miR-208 have been found to be muscle-specific, and thus have been called myomiRs. The discovery of myomiRs as a previously unrecognized component in the regulation of gene expression adds an entirely new layer of complexity to our understanding of cardiac muscle development. Investigating myomiRs will not only reveal novel molecular mechanisms of the miRNA-mediated regulatory network in cardiomyocyte development, but also raise new opportunities for therapeutic intervention for cardiovascular disease.
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影响因子：
14.9
作者：
Griffiths-Jones, S
通讯作者：
Griffiths-Jones, S
DOI：
10.1073/pnas.0509535102
发表时间：
2005-12-27
影响因子：
11.1
作者：
Kwon, C;Han, Z;Srivastava, D
通讯作者：
Srivastava, D
影响因子：
64.5
作者：
Lewis, BP;Shih, IH;Burge, CB
通讯作者：
Burge, CB
影响因子：
10.5
作者：
Mourelatos, Z;Dostie, J;Dreyfuss, G
通讯作者：
Dreyfuss, G
DOI：
10.1073/pnas.0710228105
发表时间：
2008-02-12
影响因子：
11.1
作者：
Chen, Jian-Fu;Murchison, Elizabeth P.;Wang, Da-Zhi
通讯作者：
Wang, Da-Zhi