Effects of a randomized-controlled trial of cognitive behavioral stress management: Psychosocial adaptation and immune status in men with early-stage prostate cancer.
Effects of a randomized-controlled trial of cognitive behavioral stress management: Psychosocial adaptation and immune status in men with early-stage prostate cancer.
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DOI：
10.1016/j.genhosppsych.2022.10.012
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发表时间：
2022-11
影响因子：
7
通讯作者：
Penedo, Frank J.
中科院分区：
文献类型：
--
作者：
Walsh, Emily A.;Antoni, Michael H.;Popok, Paula J.;Moreno, Patricia I.;Penedo, Frank J.
关键词：
认知行为压力管理（CBSM）的干预目标，例如益处发现（BF）和感知压力管理技能（PSMS），可能会抵消影响免疫系统的压力相关变化。这项研究测试了BF，PSMS和乐观是否会影响CBSM对前列腺癌患者免疫状态的影响。前列腺癌男性患者随机接受CBSM或心理教育（PE）对照比较（NCT 05486754）。生活取向测试-修订评估基线乐观。效益发现量表和现状量表测量了CBSM后的BF和PSMS。T细胞和T辅助细胞在基线和CBSM后6个月捕获免疫状态变化。MPlus和SPSS（PROCESS）测试了条件效应和调节中介，控制协变量。入组了256例主要为中年、白色非西班牙裔或西班牙裔男性。PSMS介导的CBSM对T细胞和T辅助细胞百分比的影响，使得通过PSMS在CBSM中与PE相比，男性中的T细胞和T辅助细胞百分比降低。乐观缓和这种调解与PSMS的中介作用，只观察到男性与平均乐观与低或高乐观。基线心理特征以及免疫测量的有限特异性可以解释该样本中的条件效应。
Targets of intervention in cognitive behavioral stress management (CBSM), such as benefit finding (BF) and perceived stress management skills (PSMS), may counteract stress-related changes that impact the immune system. This study tested whether BF, PSMS, and optimism influence the effects of CBSM on immune status in men with prostate cancer. Men with prostate cancer were randomized to receive CBSM or a psychoeducation (PE) control comparison (NCT05486754). Life Orientation Test-Revised assessed baseline optimism. The Benefit Finding Scale and Measure of Current Status measured BF and PSMS after CBSM. T-cells and T-helper cells captured immune status change at baseline and 6-months post-CBSM. MPlus and SPSS (PROCESS) tested condition effects and moderated mediation, controlling for covariates. 256 primarily middle-aged, White Non-Hispanic or Hispanic men enrolled. PSMS mediated CBSM effects on T-cell and T-helper cell percentage, such that T-cell and T-helper cell percentages were reduced in men in CBSM versus PE via PSMS. Optimism moderated this mediation with the mediating effect of PSMS only observed among men with average optimism versus those with low or high optimism. Baseline psychological characteristics, as well as limited specificity of immune measurement, could explain the conditional effects in this sample.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
12.8
作者：
Carver, Charles S.;Scheier, Michael F.;Segerstrom, Suzanne C.
通讯作者：
Segerstrom, Suzanne C.
影响因子：
2
作者：
Chambers SK;Chung E;Wittert G;Hyde MK
通讯作者：
Hyde MK
影响因子：
3.6
作者：
Bluethmann SM;Basen-Engquist K;Vernon SW;Cox M;Gabriel KP;Stansberry SA;Carmack CL;Blalock JA;Demark-Wahnefried W
通讯作者：
Demark-Wahnefried W
影响因子：
3.7
作者：
Diaz, Alain;Taub, Chloe J.;Lippman, Marc E.;Antoni, Michael H.;Blomberg, Bonnie B.
通讯作者：
Blomberg, Bonnie B.