Possible autoregulatory functions of the secretory products of mononuclear phagocytes.

Possible autoregulatory functions of the secretory products of mononuclear phagocytes.
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单核吞噬细胞分泌产物的可能的自我调节功能。

DOI:
10.1007/978-1-4757-1445-6_10
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发表时间:
1984
期刊:
Contemporary topics in immunobiology
影响因子:
--
通讯作者:
P. Davies
P. Davies
中科院分区:
--
文献类型:
--
作者:
R. Bonney;P. Davies

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自Metchnikoff的开创性观察以来,单核吞噬细胞识别、摄取和消化或通过各种出口从体内清除各种各样的传染性病原体和有毒物质的能力已被认识到。单核细胞吞噬细胞具有促进这些功能的专门识别机制,包括(1)几类免疫复合物的Fc受体;(2)对淋巴因子的反应性,用于增强其吞噬和杀灭功能;和(3)补体成分的受体,具有趋化性或促进吞噬作用。在过去的十年中,很明显,这些活动,主要涉及从宿主环境中去除有害刺激,伴随着其他专门的功能,对单核吞噬细胞的细胞周围环境中存在的细胞和结缔组织具有深远的影响。其中之一是将摄入物质的抗原决定簇以免疫原性形式呈现给免疫系统细胞的能力(有关综述,请参阅Rosenthal,1980),此处未讨论。另一个是单核吞噬细胞分泌多种产物的能力,在过去十年中吸引了许多研究人员。
The ability of mononuclear phagocytes to recognize, ingest, and either digest or remove through various portals of exit from the body a wide variety of infectious agents and toxic materials has been recognized since the seminal observations of Metchnikoff. Mononuclear phagocytes have specialized recognition mechanisms that facilitate these functions, which include (1) several classes of Fc receptors for immune complexes; (2) responsiveness to lymphokines, which serve to enhance their phagocytic and cidal functions; and (3) receptors for complement components, which are either chemotactic or facilitate phagocytosis. During the past decade it became clear that these activities, concerned primarily with the removal of noxious stimuli from the host environment, are accompanied by other specialized functions that have far-reaching effects on the cells and connective tissues present in the pericellular environment of the mononuclear phagocyte. One of these, the ability to present antigenic determinants of ingested materials to cells of the immune system in an immunogenic form (for review, see Rosenthal, 1980), is not discussed here. The other, the ability of mononuclear phagocytes to secrete a diverse range of products, preoccupied many investigators during the past decade.
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