Weight gain in pregnancy and childhood body composition: findings from the Southampton Women's Survey.
Weight gain in pregnancy and childhood body composition: findings from the Southampton Women's Survey.
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DOI：
10.3945/ajcn.2009.29128
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Southampton Women's Survey Study Group
中科院分区：
文献类型：
--
作者：
Crozier SR;Inskip HM;Godfrey KM;Cooper C;Harvey NC;Cole ZA;Robinson SM;Southampton Women's Survey Study Group
宫内生活可能是一个关键时期，规划以后的肥胖，但有相互矛盾的证据是否怀孕体重增加是一个重要的决定因素，后代肥胖。本研究的目的是探讨妊娠期体重增加与新生儿和儿童身体成分的关系。参与者（n=948）出生的儿童的妇女在南安普顿妇女的调查谁有双能X射线吸收测量身体成分在出生时，4或6年。妊娠期体重增加来源于母亲在妊娠前和妊娠34周时测量的体重，使用2009年医学研究所（IOM）分类（不足，充分或过度）进行分析，并作为连续测量。几乎一半（49%）的孩子是由怀孕期间体重超标的妇女所生。与体重增加足够的女性所生的孩子相比，新生儿期（0.17 SD（95% CI 0.02，0.32），P=0.03）、4年（0.17 SD（0.00，0.34），P=0.05）和6年（0.30 SD（0.11，0.49），P=0.002）的脂肪量更大。妊娠期体重增加越多，作为一个连续的措施，与新生儿脂肪量越大有关（0.10 SD/5 kg体重增加（0.04，0.15），P=0.0004），6年时脂肪量较弱（0.07 SD/5 kg（0.00，0.14），P=0.05），但在4年时没有（0.02 SD/5 kg（-0.04，0.08），P=0.55）。根据2009年IOM建议的定义，适当的怀孕体重增加与后代肥胖水平较低有关。
Intrauterine life may be a critical period for the programming of later obesity, but there is conflicting evidence about whether pregnancy weight gain is an important determinant of offspring adiposity. The purpose of this study was to examine the relationship of pregnancy weight gain with neonatal and childhood body composition. The participants (n=948) were children born to women in the Southampton Women’s Survey who had dual-energy x-ray absorptiometry measurements of body composition at birth, 4 or 6 years. Pregnancy weight gain was derived from the mothers’ measured weights before pregnancy and at 34 weeks gestation, analyzed using 2009 Institute of Medicine (IOM) categories (inadequate, adequate or excessive), and as a continuous measure. Almost half (49%) the children were born to women who gained excessive weight in pregnancy. In comparison with children born to women with adequate weight gain, they had a greater fat mass in the neonatal period (0.17 SD (95% CI 0.02, 0.32), P=0.03), at 4 years (0.17 SD (0.00, 0.34), P=0.05) and at 6 years (0.30 SD (0.11, 0.49), P=0.002). Greater pregnancy weight gain, as a continuous measure, was associated with greater neonatal fat mass (0.10 SD per 5kg weight gain (0.04, 0.15), P=0.0004) and, weakly, with fat mass at 6 years (0.07 SD per 5kg (0.00, 0.14), P=0.05), but not at 4 years (0.02 SD per 5kg (−0.04, 0.08), P=0.55). Appropriate pregnancy weight gain, as defined by 2009 IOM recommendations, is linked to lower levels of adiposity in the offspring.
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