Spectroscopic AC Susceptibility Imaging (sASI) of Magnetic Nanoparticles.
Spectroscopic AC Susceptibility Imaging (sASI) of Magnetic Nanoparticles.
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DOI：
10.1016/j.jmmm.2014.10.011
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发表时间：
2015-02-01
影响因子：
2.7
通讯作者：
Diamond SG
中科院分区：
文献类型：
--
作者：
Ficko BW;Nadar PM;Diamond SG
本研究展示了一种使用低成本仪器对磁性纳米颗粒（mNPs）进行交流电（AC）磁化率成像（ASI）的方法。ASI方法使用交流磁化率测量，利用驱动线圈、补偿线圈和磁通门磁强计阵列来创建断层成像图像。使用光谱方法与ASI相结合，可以为每个频率测量创建一系列层析图像，称为sASI。sASI的优点是mNPs可以在生物介质中同时表征和成像。通过将水动力直径为100 nm的mNP样品的相内和相外磁化率测量值拟合到布朗松弛模型（R2 = 0.96）来进行系统校准。在0.5 ml的试管中制备芯径为10和40 nm的mNPs样品和水动力直径为100 nm的mNPs样品。将三个mNP样本随机排列，然后使用sASI在425和925 Hz之间的六个频率进行扫描。sASI扫描显示mNP样本的位置和数量（R2 = 0.97）。通过扫描注射到猪肉香肠中的mNPs，证明了sASI方法的生物相容性。生物培养基中的mNP响应与校准样品相关（R2 = 0.97, p <0.001）。这些结果证明了ASI的概念和sASI的优势。
This study demonstrates a method for alternating current (AC) susceptibility imaging (ASI) of magnetic nanoparticles (mNPs) using low cost instrumentation. The ASI method uses AC magnetic susceptibility measurement to create tomographic images using an array of drive coils, compensation coils and fluxgate magnetometers. Using a spectroscopic approach in conjunction with ASI, a series of tomographic images can be created for each frequency measurement and is termed sASI. The advantage of sASI is that mNPs can be simultaneously characterized and imaged in a biological medium. System calibration was performed by fitting the in-phase and out-of-phase susceptibility measurements of an mNP sample with a hydrodynamic diameter of 100 nm to a Brownian relaxation model (R2 = 0.96). Samples of mNPs with core diameters of 10 and 40 nm and a sample of 100 nm hydrodynamic diameter were prepared in 0.5 ml tubes. Three mNP samples were arranged in a randomized array and then scanned using sASI with six frequencies between 425 and 925 Hz. The sASI scans showed the location and quantity of the mNP samples (R2 = 0.97). Biological compatibility of the sASI method was demonstrated by scanning mNPs that were injected into a pork sausage. The mNP response in the biological medium was found to correlate with a calibration sample (R2 = 0.97, p <0.001). These results demonstrate the concept of ASI and advantages of sASI.
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影响因子：
3.8
作者：
Anninga, Bauke;Ahmed, Muneer;Douek, Michael
通讯作者：
Douek, Michael
影响因子：
4.8
作者：
de Montferrand, C.;Milosevic, I.;Motte, L.
通讯作者：
Motte, L.
影响因子：
3.5
作者：
Adolphi NL;Huber DL;Bryant HC;Monson TC;Fegan DL;Lim J;Trujillo JE;Tessier TE;Lovato DM;Butler KS;Provencio PP;Hathaway HJ;Majetich SA;Larson RS;Flynn ER
通讯作者：
Flynn ER
影响因子：
2.1
作者：
Nakamura, Kosuke;Ueda, Koji;Takemura, Yasushi
通讯作者：
Takemura, Yasushi
影响因子：
64.8
作者：
Gleich, B;Weizenecker, R
通讯作者：
Weizenecker, R