Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries.
Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries.
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淋巴细胞染色体畸变频率可预测癌症风险：来自 11 个国家 22 358 名受试者的队列研究结果。
DOI：
10.1093/carcin/bgn075
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发表时间：
2008-06
期刊：
影响因子：
4.7
通讯作者：
Boffetta P
中科院分区：
文献类型：
--
作者：
Bonassi S;Norppa H;Ceppi M;Strömberg U;Vermeulen R;Znaor A;Cebulska-Wasilewska A;Fabianova E;Fucic A;Gundy S;Hansteen IL;Knudsen LE;Lazutka J;Rossner P;Sram RJ;Boffetta P
将染色体畸变（CA）与癌症早期阶段相关联的机制性证据最近得到了流行病学研究结果的支持，这些研究将健康个体外周淋巴细胞中的CA频率与未来的癌症发病率相关联。为克服单一研究的局限性并评估这种关联的强度，进行了一项汇总分析。汇总数据库包括11个国家的队列，共有22358名无癌个体，他们在1965 - 2002年期间出于生物监测目的接受了CA基因筛查，并对癌症发病率和/或死亡率进行了平均10.1年的随访；观察到368例癌症死亡和675例癌症发病病例。在每个实验室中，根据CA频率的三分位数对受试者进行分类。与低三分位数相比，处于中等[相对风险（RR）= 1.31，95%置信区间（CI）= 1.07 - 1.60]和高（RR = 1.41；95% CI = 1.16 - 1.72）三分位数的受试者患癌症的相对风险增加。这种增加主要是由染色体型畸变驱动的。环形染色体的存在使RR增加到2.22（95% CI = 1.34 - 3.68）。发现与胃癌的关联最强[RR中等 = 1.17（95% CI = 0.37 - 3.70），RR高 = 3.13（95% CI = 1.17 - 8.39）]。致癌物暴露并未改变CA水平对总体癌症风险的影响。这些结果强化了CA频率与癌症风险之间存在联系的证据，并提供了关于畸变亚类和癌症类型作用的新信息。
Mechanistic evidence linking chromosomal aberration (CA) to early stages of cancer has been recently supported by the results of epidemiological studies that associated CA frequency in peripheral lymphocytes of healthy individuals to future cancer incidence. To overcome the limitations of single studies and to evaluate the strength of this association, a pooled analysis was carried out. The pooled database included 11 national cohorts and a total of 22 358 cancer-free individuals who underwent genetic screening with CA for biomonitoring purposes during 1965–2002 and were followed up for cancer incidence and/or mortality for an average of 10.1 years; 368 cancer deaths and 675 incident cancer cases were observed. Subjects were classified within each laboratory according to tertiles of CA frequency. The relative risk (RR) of cancer was increased for subjects in the medium [RR = 1.31, 95% confidence interval (CI) = 1.07–1.60] and in the high (RR = 1.41; 95% CI = 1.16–1.72) tertiles when compared with the low tertile. This increase was mostly driven by chromosome-type aberrations. The presence of ring chromosomes increased the RR to 2.22 (95% CI = 1.34–3.68). The strongest association was found for stomach cancer [RRmedium = 1.17 (95% CI = 0.37–3.70), RRhigh = 3.13 (95% CI = 1.17–8.39)]. Exposure to carcinogens did not modify the effect of CA levels on overall cancer risk. These results reinforce the evidence of a link between CA frequency and cancer risk and provide novel information on the role of aberration subclass and cancer type.
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影响因子：
10.4
作者：
Rossner, P;Boffetta, P;Srám, RJ
通讯作者：
Srám, RJ
影响因子：
4
作者：
SAVAGE, JRK
通讯作者：
SAVAGE, JRK
影响因子：
11.2
作者：
Hagmar, L;Strömberg, U;Norppa, H
通讯作者：
Norppa, H
DOI：
10.1073/pnas.94.7.3290
发表时间：
1997-04-01
影响因子：
11.1
作者：
Blount, BC;Mack, MM;Ames, BN
通讯作者：
Ames, BN
影响因子：
4.2
作者：
Kimura, M;Umegaki, K;Fenech, M
通讯作者：
Fenech, M