Comparison of intima-media thickness and ophthalmic artery resistance index for assessing subclinical atherosclerosis in HIV-1-infected patients.
Comparison of intima-media thickness and ophthalmic artery resistance index for assessing subclinical atherosclerosis in HIV-1-infected patients.
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DOI：
10.1186/1476-7120-9-9
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发表时间：
2011-04-01
影响因子：
1.9
通讯作者：
Zizza A
中科院分区：
文献类型：
--
作者：
Grima P;Guido M;Chiavaroli R;De Donno A;Tana M;Zizza A
人类免疫缺陷病毒（HIV）感染和抗逆转录病毒治疗与代谢和心血管并发症有关，可能会增加该人群患动脉粥样硬化和心血管疾病的风险。动脉壁厚度的测量已被用作动脉粥样硬化程度、严重程度和进展的替代指标。进行了一项横断面队列研究，以比较两种非侵入性动脉测量的有效性：颈动脉内膜中层厚度（IMT）（动脉粥样硬化的参数）和眼动脉阻力指数（OARI）（闭塞性颈动脉疾病的指数）。连续入组接受高效抗逆转录病毒治疗（HAART）超过12个月的患者95例。 IMT 和 OARI 通过 7.5 MHz 线性探头测量。 IMT 和 OARI 值随心血管风险等级呈显着线性增加（极低风险为 0.70 和 0.69，低风险为 0.86 和 0.72，中/高风险为 0.98 和 0.74，p < 0.001）。 IMT > 0.83 和 OARI > 0.72 是预测心血管风险 ≥ 10% 时最具辨别力的值（敏感性 89.6% 和 75.8%；敏感性 70.5% 和 68.4%；p < 0.001）。我们的数据表明，OARI 可能有潜力成为 HIV-1 感染患者亚临床动脉粥样硬化的新早熟标志物。
Human immunodeficiency virus (HIV) infection and antiretroviral treatment are associated with metabolic and cardiovascular complications that potentially increase the risk of atherosclerosis and cardiovascular disease in this population. Measurement of arterial wall thickness has been used as a surrogate of extent, severity and progression of atherosclerosis. A cross-sectional cohort study was performed to compare the validity of two non-invasive arterial measures: carotid intima-media thickness (IMT), a parameter of atherosclerosis, and ophthalmic artery resistance index (OARI), an index of occlusive carotid artery disease. A total of 95 patients receiving highly active antiretroviral therapy (HAART) for more than 12 months were consecutively enrolled. IMT and OARI were measured by 7.5 MHz linear probe. There was a significant linear increase in IMT and OARI values as the grade of cardiovascular risk (0.70 and 0.69 for very low risk, 0.86 and 0.72 for low risk and 0.98 and 0.74 for medium/high risk, p < 0.001). A IMT > 0.83 and an OARI > 0.72 were the most discriminatory values for predicting a cardiovascular risk ≥ 10% (sensibility 89.6% and 75.8%; sensitivity 70.5% and 68.4%; p < 0.001). Our data indicate that OARI may have a potential as a new precocious marker of subclinical atherosclerosis in HIV-1-infected patients.
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影响因子：
37.8
作者：
Wilson, PWF;D'Agostino, RB;Kannel, WB
通讯作者：
Kannel, WB
DOI：
10.1161/01.atv.13.10.1404
发表时间：
1993-10-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
WENDELHAG, I;WIKLUND, O;WIKSTRAND, J
通讯作者：
WIKSTRAND, J
影响因子：
5
作者：
Chambless, LE;Heiss, G;Clegg, LX
通讯作者：
Clegg, LX
影响因子：
37.8
作者：
Hsue, PY;Lo, JC;Waters, DD
通讯作者：
Waters, DD
DOI：
10.1016/j.echo.2007.11.011
发表时间：
2008-02-01
影响因子：
6.5
作者：
Stein, James H.;Korcarz, Claudia E.;Post, Wendy S.
通讯作者：
Post, Wendy S.