How specific is too specific? B-cell responses to viral infections reveal the importance of breadth over depth.
How specific is too specific? B-cell responses to viral infections reveal the importance of breadth over depth.
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DOI：
10.1111/imr.12094
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发表时间：
2013-09
影响因子：
8.7
通讯作者：
Baumgarth N
中科院分区：
文献类型：
--
作者：
Baumgarth N
流感病毒感染诱导强大和高度保护性的B细胞反应。从这种保护性体液反应的分析中获得的知识可以为成功的疫苗和疫苗接种方法的设计提供重要线索，并且还提供了一个窗口，可以调节B细胞反应的基本方面，当研究对非复制剂的反应时，这些方面可能不起作用。在这里，我回顾了B细胞对病毒反应的特征，重点是流感病毒感染，呼吸道上皮细胞的高度局部化感染，以及针对病毒的反应，该病毒不断经历其表面刺突蛋白的遗传变化，这是中和抗体的主要靶点。B细胞对流感的反应的两个方面在这里讨论，即多反应性天然抗体和生发中心反应的作用和功能。B细胞反应的这两个特征提出了一个问题，即抗体的精细特异性对于长期保护免受感染有多重要。如所概述的，流感病毒的发病机制和抗病毒B细胞应答的性质似乎强调库多样性超过亲和力成熟作为流感特异性B细胞免疫背后的驱动力。
Influenza virus infection induces robust and highly protective B-cell responses. Knowledge gained from the analysis of such protective humoral responses can provide important clues for the design of successful vaccines and vaccination approaches and also provides a window into the regulation of fundamental aspects of B-cell responses that may not be at play when responses to non-replicating agents are studied. Here I review features of the B-cell response to viruses, with emphasis on influenza virus infection, a highly localized infection of respiratory tract epithelial cells, and a response that is directed against a virus that continuously undergoes genetic changes to its surface spike protein, a major target of neutralizing antibodies. Two aspects of the B-cell response to influenza are discussed here, namely polyreactive natural antibodies and the role and function of germinal center responses. Both these features of the B-cell response raise the question of how important antibody fine-specificity is for long-term protection from infection. As outlined, the pathogenesis of influenza virus and the nature of the antiviral B-cell response seem to emphasize repertoire diversity over affinity maturation as driving forces behind the influenza-specific B-cell immunity.
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影响因子：
64.8
作者：
Crotty, S;Kersh, EN;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
4.4
作者：
Chang, W. L. William;Coro, Elizabeth S.;Baumgarth, Nicole
通讯作者：
Baumgarth, Nicole
影响因子：
4.4
作者：
Fairfax, Kirsten A.;Corcoran, Lynn M.;Tarlinton, David M.
通讯作者：
Tarlinton, David M.
DOI：
10.1073/pnas.0813411106
发表时间：
2009-03-17
影响因子：
11.1
作者：
Cole, Leah E.;Yang, Yang;Vogel, Stefanie N.
通讯作者：
Vogel, Stefanie N.
DOI：
10.1084/jem.20080979
发表时间：
2008-12-22
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Choi YS;Baumgarth N
通讯作者：
Baumgarth N