Dual role for B-1a cells in immunity to influenza virus infection.
Dual role for B-1a cells in immunity to influenza virus infection.
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DOI：
10.1084/jem.20080979
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发表时间：
2008-12-22
期刊：
影响因子：
--
通讯作者：
Baumgarth N
中科院分区：
文献类型：
--
作者：
Choi YS;Baumgarth N
已知B-1细胞贡献了大多数在稳定状态下分泌的“天然抗体”，这些抗体对于抵御包括流感病毒在内的许多病原体至关重要。CD5+ B-1a亚群是否在主动免疫反应中发挥作用尚不完全清楚。与最近的数据显示B-1a细胞的被动作用相反，本研究提供的数据显示，流感感染后，呼吸道引流淋巴结中的B-1细胞高度局部活化。B-1细胞被确定为稳态和感染诱导的局部病毒中和性IgM的主要来源。CD5+ B-1a亚群是产生这种反应的主要B-1细胞亚群。B-1a细胞反应是由它们增加的局部积累而不是抗原特异性扩增产生的。我们的研究表明，在流感感染期间，表达cd5的B-1a细胞响应并有助于保护，可能不需要B细胞受体介导的抗原特异性信号，已知这些信号会诱导B-1a细胞死亡而不是激活。因此，我们的数据揭示了感染期间B-1和B-2细胞反应调节的根本差异。
B-1 cells are known to contribute most of the “natural antibodies” that are secreted in the steady state, antibodies which are crucial for protection against many pathogens including influenza virus. Whether the CD5+ B-1a subset plays a role during an active immune response is incompletely understood. In contrast to recent data suggesting a passive role for B-1a cells, data provided here show strong highly localized activation of B-1 cells in the draining lymph nodes of the respiratory tract after influenza infection. B-1 cells are identified as a major source for both steady state and infection-induced local virus-neutralizing IgM. The CD5+ B-1a subset is the main B-1 cell subset generating this response. B-1a cell responses are generated by their increased local accumulation rather than by antigen-specific expansion. Our study reveals that during infection with influenza, CD5-expressing B-1a cells respond to and contribute to protection, presumably without the need for B cell receptor–mediated antigen-specific signals, which are known to induce the death of B-1a cells rather than activation. With that, our data reveal fundamental differences in the response regulation of B-1 and B-2 cells during an infection.
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影响因子：
32.4
作者：
Alugupalli, KR;Leong, JM;Gerstein, RM
通讯作者：
Gerstein, RM
影响因子：
5.4
作者：
Jayasekera, Jerome P.;Moseman, E. Ashley;Carroll, Michael C.
通讯作者：
Carroll, Michael C.
通过信号通过Toll样受体来调节B1细胞迁移。
DOI：
10.1084/jem.20061041
发表时间：
2006-10-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ha SA;Tsuji M;Suzuki K;Meek B;Yasuda N;Kaisho T;Fagarasan S
通讯作者：
Fagarasan S
影响因子：
32.4
作者：
Jego, G;Palucka, AK;Banchereau, J
通讯作者：
Banchereau, J
影响因子：
2.2
作者：
Bachmann, MF;Ecabert, B;Kopf, M
通讯作者：
Kopf, M