17 β -Estradiol attenuates poststroke depression and increases neurogenesis in female ovariectomized rats.
17 β -Estradiol attenuates poststroke depression and increases neurogenesis in female ovariectomized rats.
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DOI：
10.1155/2013/392434
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发表时间：
2013
影响因子：
--
通讯作者：
Jin K
中科院分区：
文献类型：
--
作者：
Cheng Y;Su Q;Shao B;Cheng J;Wang H;Wang L;Lin Z;Ruan L;ZhuGe Q;Jin K
研究已经将神经发生与特定抗抑郁药的有益作用联系起来。然而，17β-雌二醇（E2），一种抗抑郁药，是否可以改善卒中后抑郁症（PSD），以及E2介导的PSD改善是否与神经发生有关，在很大程度上尚未探索。在本研究中，我们发现，抑郁样行为局灶性脑缺血（OVX）雌性大鼠脑卒中后第一周观察到，通过蔗糖偏好和开放领域的测试，表明局灶性脑缺血可以诱导PSD。大脑中动脉阻塞（MCAO）后3周，连续14天给予E2。我们发现，E2治疗组大鼠在强迫游泳实验和蔗糖偏好实验中，与溶剂治疗组相比，显著改善缺血诱导的抑郁样行为。此外，我们还发现，BrdU-和doublecortin（DCX）-阳性细胞在海马齿状回和脑室下区（SVZ）的缺血大鼠后E2治疗组显着增加，与溶剂治疗组相比。提示局灶性脑缺血可诱发PSD，E2可改善PSD。此外，海马新生神经元可能在缺血性卒中后E2介导的抗抑郁样作用中发挥重要作用。
Studies have linked neurogenesis to the beneficial actions of specific antidepressants. However, whether 17β-estradiol (E2), an antidepressant, can ameliorate poststroke depression (PSD) and whether E2-mediated improvement of PSD is associated with neurogenesis are largely unexplored. In the present study, we found that depressive-like behaviors were observed at the first week after focal ischemic stroke in female ovariectomized (OVX) rats, as measured by sucrose preference and open field test, suggesting that focal cerebral ischemia could induce PSD. Three weeks after middle cerebral artery occlusion (MCAO), rats were treated with E2 for consecutive 14 days. We found that E2-treated rats had significantly improving ischemia-induced depression-like behaviors in the forced-swimming test and sucrose preference test, compared to vehicle-treated group. In addition, we also found that BrdU- and doublecortin (DCX)-positive cells in the dentate gyrus of the hippocampus and the subventricular zone (SVZ) were significantly increased in ischemic rats after E2 treatment, compared to vehicle-treated group. Our data suggest that focal cerebral ischemia can induce PSD, and E2 can ameliorate PSD. In addition, newborn neurons in the hippocampus may play an important role in E2-mediated antidepressant like effect after ischemic stroke.
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影响因子：
56.9
作者：
Santarelli, L;Saxe, M;Hen, R
通讯作者：
Hen, R
影响因子：
3.3
作者：
Barker, J. M.;Galea, L. A. M.
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影响因子：
15.1
作者：
Guan, ZW;Fang, JD
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影响因子：
5.3
作者：
Nixon, K;Crews, FT
通讯作者：
Crews, FT
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7.6
作者：
Estrada-Camarena, E;Fernández-Guasti, A;López-Rubalcava, C
通讯作者：
López-Rubalcava, C