Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model.
Acute regional changes in myocardial strain may predict ventricular remodelling after myocardial infarction in a large animal model.
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DOI：
10.1038/s41598-021-97834-y
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发表时间：
2021-09-15
影响因子：
4.6
通讯作者：
Cookson AN
中科院分区：
文献类型：
--
作者：
Mansell DS;Bruno VD;Sammut E;Chiribiri A;Johnson T;Khaliulin I;Lopez DB;Gill HS;Fraser KH;Murphy M;Krieg T;Suleiman MS;George S;Ascione R;Cookson AN
为了确定心肌梗死（MI）后左心室重构（LVR）的预测因子和相关分子特征，使用了猪闭胸球囊MI模型，沿着MI后5-6周的连续心脏磁共振成像（CMRI）。心肌应变和应变率的变化来自CMRI数据。组织蛋白质组学比较梗死和非梗死领土。左心室（LV）心尖周向应变（ACS）的峰值随时间变化，与峰值整体周向应变（GCS），而峰值GLS心外膜应变或应变率不随时间变化。MI后早期LVR增强了梗死LV区域中39种蛋白的丰度，其中21种与LV赤道周向应变率相关。观察到D-3-磷酸甘油酸脱氢酶（D-3 PGDH）、半胱氨酸和富含甘氨酸的蛋白-2和分泌型卷曲相关蛋白1（sFRP 1）的关联性最强。这项研究表明，局部峰值ACS的早期变化持续在MI后5-6周，此时观察到早期LVR沿着D-3 PGDH和sFRP 1的组织水平增加。需要更多的研究来确定观察到的D-3 PGDH和sFRP 1的组织水平的增加是否可能偶然地参与了不利的LV重构的发病机制。
To identify predictors of left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used along with serial cardiac magnetic resonance imaging (CMRI) up to 5–6 weeks post-MI. Changes in myocardial strain and strain rates were derived from CMRI data. Tissue proteomics was compared between infarcted and non-infarcted territories. Peak values of left ventricular (LV) apical circumferential strain (ACS) changed over time together with peak global circumferential strain (GCS) while peak GLS epicardial strains or strain rates did not change over time. Early LVR post-MI enhanced abundance of 39 proteins in infarcted LV territories, 21 of which correlated with LV equatorial circumferential strain rate. The strongest associations were observed for D-3-phosphoglycerate dehydrogenase (D-3PGDH), cysteine and glycine-rich protein-2, and secreted frizzled-related protein 1 (sFRP1). This study shows that early changes in regional peak ACS persist at 5–6 weeks post-MI, when early LVR is observed along with increased tissue levels of D-3PGDH and sFRP1. More studies are needed to ascertain if the observed increase in tissue levels of D-3PGDH and sFRP1 might be casually involved in the pathogenesis of adverse LV remodelling.
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影响因子：
24
作者：
Chan, Jonathan;Hanekom, Lizelle;Marwick, Thomas H.
通讯作者：
Marwick, Thomas H.
影响因子：
37.8
作者：
Dufourcq, P;Couffinhal, T;Duplàa, C
通讯作者：
Duplàa, C
影响因子：
37.8
作者：
Benjamin, Emelia J.;Virani, Salim S.;Muntner, Paul
通讯作者：
Muntner, Paul
影响因子：
3.8
作者：
Lindsey ML;Hall ME;Harmancey R;Ma Y
通讯作者：
Ma Y
影响因子：
4.6
作者：
Nishita M;Park SY;Nishio T;Kamizaki K;Wang Z;Tamada K;Takumi T;Hashimoto R;Otani H;Pazour GJ;Hsu VW;Minami Y
通讯作者：
Minami Y