The Adipose Organ Is a Unitary Structure in Mice and Humans.
The Adipose Organ Is a Unitary Structure in Mice and Humans.
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DOI：
10.3390/biomedicines10092275
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发表时间：
2022-09-14
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
肥胖是全球第五大死因。在肥胖的小鼠和人类中，脂肪器官经历了显著的形态功能改变。了解脂肪器官的功能和组织对了解其病理和制定未来的治疗策略至关重要。在本研究中，我们对人类和小鼠的脂肪组织进行了解剖解剖、磁共振成像、计算机轴向断层扫描以及组织学和免疫组织化学评估。我们证明，大多数两种类型的脂肪组织（白色，WAT和棕色，BAT）形成一个大的单一结构，满足所有必要的要求，被认为是一个真正的器官，在这两个物种。对不同病理生理状态（正常、寒冷、妊娠、肥胖）小鼠脂肪器官大体解剖的详细分析表明，该器官是由不同组织组成的统一结构：WAT、BAT和腺体（妊娠）。8具尸体（2女6男）（年龄：37.5±9.7,BMI: 23±2.7 kg/m2）和4具尸体（2女2男）（年龄：39±14.2岁，BMI: 22.8±4.3 kg/m2）的详细数字解剖数据证实了人类脂肪器官的混合（WAT和BAT）组成和单一结构。考虑到WAT和BAT显著的内分泌作用，内分泌脂肪器官的定义在小鼠和人类中更为合适。
Obesity is the fifth leading cause of death worldwide. In mice and humans with obesity, the adipose organ undergoes remarkable morpho-functional alterations. The comprehension of the adipose organ function and organization is of paramount importance to understand its pathology and formulate future therapeutic strategies. In the present study, we performed anatomical dissections, magnetic resonance imaging, computed axial tomography and histological and immunohistochemical assessments of humans and mouse adipose tissues. We demonstrate that most of the two types of adipose tissues (white, WAT and brown, BAT) form a large unitary structure fulfilling all the requirements necessary to be considered as a true organ in both species. A detailed analysis of the gross anatomy of mouse adipose organs in different pathophysiological conditions (normal, cold, pregnancy, obesity) shows that the organ consists of a unitary structure composed of different tissues: WAT, BAT, and glands (pregnancy). Data from autoptic dissection of 8 cadavers, 2 females and 6 males (Age: 37.5 ± 9.7, BMI: 23 ± 2.7 kg/m2) and from detailed digital dissection of 4 digitalized cadavers, 2 females and 2 males (Age: 39 ± 14.2 years, BMI: 22.8 ± 4.3 kg/m2) confirmed the mixed (WAT and BAT) composition and the unitary structure of the adipose organ also in humans. Considering the remarkable endocrine roles of WAT and BAT, the definition of the endocrine adipose organ would be even more appropriate in mice and humans.
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影响因子：
16.6
作者：
Berbée JF;Boon MR;Khedoe PP;Bartelt A;Schlein C;Worthmann A;Kooijman S;Hoeke G;Mol IM;John C;Jung C;Vazirpanah N;Brouwers LP;Gordts PL;Esko JD;Hiemstra PS;Havekes LM;Scheja L;Heeren J;Rensen PC
通讯作者：
Rensen PC
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
29
作者：
Altshuler-Keylin S;Shinoda K;Hasegawa Y;Ikeda K;Hong H;Kang Q;Yang Y;Perera RM;Debnath J;Kajimura S
通讯作者：
Kajimura S
影响因子：
1.2
作者：
Chung，Beom Sun;Park，Hyo Seok;Chung，Min Suk
通讯作者：
Chung，Min Suk
影响因子：
15.9
作者：
Fisher, MH;Amend, AM;MacIntyre, DE
通讯作者：
MacIntyre, DE