A single-cell atlas of human and mouse white adipose tissue.
A single-cell atlas of human and mouse white adipose tissue.
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DOI：
10.1038/s41586-022-04518-2
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发表时间：
2022-03
期刊：
影响因子：
64.8
通讯作者：
中科院分区：
文献类型：
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白色脂肪组织（WAT）曾被认为在形态和功能上是温和的，现在被认为是动态的、可塑的、异质的，并且参与广泛的生物过程，包括能量稳态、葡萄糖和脂质处理、血压控制和宿主防御。高脂肪喂养和其他代谢应激因素导致脂肪形态、生理和细胞组成的显著变化，并且肥胖的改变与胰岛素抵抗、血脂异常和2型糖尿病（T2D）相关。在这里，我们提供了详细的细胞图谱，人类和小鼠皮下和内脏白色脂肪在单细胞分辨率在一个体重范围。我们鉴定了脂肪细胞、脂肪干细胞和祖细胞（ASPC）、血管细胞和免疫细胞的亚群，并证明了不同物种和饮食条件下的共性和差异。我们将特定细胞类型与代谢疾病风险增加联系起来，并为消瘦和肥胖的脂肪生态位中单个细胞类型之间的一系列全面相互作用提供了初步蓝图。这些数据包括一个广泛的资源，用于探索跨物种，仓库和营养条件下WAT功能的基因，性状和细胞类型。
White adipose tissue (WAT), once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic, heterogenous, and involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control, and host defense. High fat feeding and other metabolic stressors cause dramatic changes in adipose morphology, physiology, and cellular composition, and alterations in adiposity are associated with insulin resistance, dyslipidemia, and type 2 diabetes (T2D). Here, we provide detailed cellular atlases of human and murine subcutaneous and visceral white fat at single cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells (ASPCs), vascular, and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease, and we provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits, and cell types in the function of WAT across species, depots, and nutritional conditions.
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影响因子：
30.8
作者：
Das, Sayantan;Forer, Lukas;Schoenherr, Sebastian;Sidore, Carlo;Locke, Adam E.;Kwong, Alan;Vrieze, Scott I.;Chew, Emily Y.;Levy, Shawn;McGue, Matt;Schlessinger, David;Stambolian, Dwight;Loh, Po-Ru;Iacono, William G.;Swaroop, Anand;Scott, Laura J.;Cucca, Francesco;Kronenberg, Florian;Boehnke, Michael;Abecasis, Goncalo R.;Fuchsberger, Christian
通讯作者：
Fuchsberger, Christian
影响因子：
30.8
作者：
Finucane HK;Bulik-Sullivan B;Gusev A;Trynka G;Reshef Y;Loh PR;Anttila V;Xu H;Zang C;Farh K;Ripke S;Day FR;ReproGen Consortium;Schizophrenia Working Group of the Psychiatric Genomics Consortium;RACI Consortium;Purcell S;Stahl E;Lindstrom S;Perry JR;Okada Y;Raychaudhuri S;Daly MJ;Patterson N;Neale BM;Price AL
通讯作者：
Price AL
影响因子：
64.8
作者：
Kahn, Steven E.;Hull, Rebecca L.;Utzschneider, Kristina M.
通讯作者：
Utzschneider, Kristina M.
DOI：
10.1016/j.dsx.2018.11.043
发表时间：
2019-01-01
影响因子：
10
作者：
Benites-Zapata, Vicente A.;Toro-Huamanchumo, Carlos J.;del Carmen Ranilla-Seguin, Vitalia
通讯作者：
del Carmen Ranilla-Seguin, Vitalia
新的遗传基因座涉及禁食葡萄糖稳态及其对2型糖尿病风险的影响。
影响因子：
30.8
作者：
通讯作者：
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