Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy.
Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy.
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DOI：
10.3390/ijms18071506
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发表时间：
2017-07-12
影响因子：
5.6
通讯作者：
Almeida LO
中科院分区：
文献类型：
--
作者：
Castilho RM;Squarize CH;Almeida LO
头颈部鳞状细胞癌（Head and Neck Squamous Carcinoma，HNSCC）是世界上第六大常见的恶性肿瘤，也是最具侵袭性的恶性肿瘤之一。尽管不断努力鉴定用于早期检测的分子标志物，并开发有效的治疗方法，但HNSCC患者的总体生存率和预后仍然很差。越来越多的科学证据表明，表观遗传学改变，包括DNA甲基化，组蛋白共价修饰，染色质重塑和非编码RNA，经常参与口腔癌的发生，肿瘤的进展和耐药治疗。表观遗传学改变以非系统的方式或作为异常转录机制的一部分发生，其促进肿瘤细胞的选择性优势。表观遗传修饰还有助于肿瘤进展期间的细胞可塑性和癌症干细胞（CSC）（具有自我更新能力的肿瘤细胞的一小部分）的形成。CSC参与内在或获得性治疗抗性的发展，以及肿瘤复发或复发。因此，理解和表征与头颈部癌发生相关的表观遗传修饰，以及前瞻性地鉴定与CSC相关的表观遗传标记，为对抗肿瘤的新治疗策略带来了希望。在这篇综述中，我们专注于目前的知识，在HNSCC和新兴的Epi-drugs能够敏感HNSCC治疗观察到的表观遗传修饰。
Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one of the most aggressive malignancies worldwide. Despite continuous efforts to identify molecular markers for early detection, and to develop efficient treatments, the overall survival and prognosis of HNSCC patients remain poor. Accumulated scientific evidences suggest that epigenetic alterations, including DNA methylation, histone covalent modifications, chromatin remodeling and non-coding RNAs, are frequently involved in oral carcinogenesis, tumor progression, and resistance to therapy. Epigenetic alterations occur in an unsystematic manner or as part of the aberrant transcriptional machinery, which promotes selective advantage to the tumor cells. Epigenetic modifications also contribute to cellular plasticity during tumor progression and to the formation of cancer stem cells (CSCs), a small subset of tumor cells with self-renewal ability. CSCs are involved in the development of intrinsic or acquired therapy resistance, and tumor recurrences or relapse. Therefore, the understanding and characterization of epigenetic modifications associated with head and neck carcinogenesis, and the prospective identification of epigenetic markers associated with CSCs, hold the promise for novel therapeutic strategies to fight tumors. In this review, we focus on the current knowledge on epigenetic modifications observed in HNSCC and emerging Epi-drugs capable of sensitizing HNSCC to therapy.
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影响因子：
1.2
作者：
Almeida LO;Guimarães DM;Martins MD;Martins MAT;Warner KA;Nör JE;Castilho RM;Squarize CH
通讯作者：
Squarize CH
影响因子：
11.2
作者：
Choi, Jung Hye;Sheu, Jim Jinn-Chyuan;Guan, Bin;Jinawath, Natini;Markowski, Paul;Wang, Tian-Li;Shih, Ie-Ming
通讯作者：
Shih, Ie-Ming
影响因子：
5.7
作者：
Baba, Seiji;Yamada, Yasuhiro;Hara, Akira
通讯作者：
Hara, Akira
影响因子：
2.6
作者：
Almeida LO;Abrahao AC;Rosselli-Murai LK;Giudice FS;Zagni C;Leopoldino AM;Squarize CH;Castilho RM
通讯作者：
Castilho RM
影响因子：
4.8
作者：
Chang, Hao-Hueng;Chiang, Chun-Pin;Kuo, Mark Yen-Ping
通讯作者：
Kuo, Mark Yen-Ping