Advances in research into gamete and embryo-fetal origins of adult diseases
Advances in research into gamete and embryo-fetal origins of adult diseases
复制标题
成人疾病配子和胚胎-胎儿起源的研究进展
DOI：
10.1007/s11427-018-9427-4
复制
发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Huang Hefeng
中科院分区：
文献类型：
--
作者：
Zou Kexin;Ding Guolian;Huang Hefeng
成人疾病的胎儿和婴儿起源假说提出，成人慢性疾病的根源在于胎儿生活和婴儿期早期不良环境的影响。除了胚胎期、受精期和胚胎早期，表观遗传重编程、细胞快速分化和器官发生的关键时间窗是对环境干扰最敏感的阶段。与胚胎和胎儿发育相比，配子发生和成熟需要几十年的时间，暴露时间越长，就越容易受到潜在的伤害。因此，我们应该将成人疾病的发生和发病机制的重点进一步转移到配子体发生和胚胎发育事件上，这可能导致代际甚至跨代的表观遗传重编程，并将不利的性状和特征传递给后代。本文就配子和早期胚胎事件引起的疾病及其潜在的表观遗传机制的研究进展作一综述。
The fetal and infant origins of adult disease hypothesis proposed that the roots of adult chronic disease lie in the effects of adverse environments in fetal life and early infancy. In addition to the fetal period, fertilization and early embryonic stages, the critical time windows of epigenetic reprogramming, rapid cell differentiation and organogenesis, are the most sensitive stages to environmental disturbances. Compared with embryo and fetal development, gametogenesis and maturation take decades and are more vulnerable to potential damage for a longer exposure period. Therefore, we should shift the focus of adult disease occurrence and pathogenesis further back to gametogenesis and embryonic development events, which may result in intergenerational, even transgenerational, epigenetic re-programming with transmission of adverse traits and characteristics to offspring. Here, we focus on the research progress relating to diseases that originated from events in the gametes and early embryos and the potential epigenetic mechanisms involved.
登录
查看更多内容
Dnmt2通过精子小非编码RNA介导父系获得性代谢紊乱的代际传播
影响因子：
21.3
作者：
Zhang Y;Zhang X;Shi J;Tuorto F;Li X;Liu Y;Liebers R;Zhang L;Qu Y;Qian J;Pahima M;Liu Y;Yan M;Cao Z;Lei X;Cao Y;Peng H;Liu S;Wang Y;Zheng H;Woolsey R;Quilici D;Zhai Q;Li L;Zhou T;Yan W;Lyko F;Zhang Y;Zhou Q;Duan E;Chen Q
通讯作者：
Chen Q
影响因子：
3.7
作者：
Eckert JJ;Porter R;Watkins AJ;Burt E;Brooks S;Leese HJ;Humpherson PG;Cameron IT;Fleming TP
通讯作者：
Fleming TP
影响因子：
3.5
作者：
Bahous RH;Jadavji NM;Deng L;Cosín-Tomás M;Lu J;Malysheva O;Leung KY;Ho MK;Pallàs M;Kaliman P;Greene NDE;Bedell BJ;Caudill MA;Rozen R
通讯作者：
Rozen R
影响因子：
64.5
作者：
Gkountela S;Zhang KX;Shafiq TA;Liao WW;Hargan-Calvopiña J;Chen PY;Clark AT
通讯作者：
Clark AT
影响因子：
25
作者：
Gapp, Katharina;Jawaid, Ali;Sarkies, Peter;Bohacek, Johannes;Pelczar, Pawel;Prados, Julien;Farinelli, Laurent;Miska, Eric;Mansuy, Isabelle M.
通讯作者：
Mansuy, Isabelle M.