Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.
Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.
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DOI：
10.1038/nn.3695
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发表时间：
2014-05
影响因子：
25
通讯作者：
Mansuy, Isabelle M.
中科院分区：
文献类型：
--
作者：
Gapp, Katharina;Jawaid, Ali;Sarkies, Peter;Bohacek, Johannes;Pelczar, Pawel;Prados, Julien;Farinelli, Laurent;Miska, Eric;Mansuy, Isabelle M.
基因环境的相互作用是精神疾病，糖尿病和癌症病因的决定因素，并被认为有助于世代相传的疾病遗传。小型非编码RNA（SNCRNA）是基因与环境之间界面的潜在向量。在这里，我们报告说，小鼠早期涉及创伤应激的环境状况改变了microRNA（miRNA）表达，以及后代的行为和代谢反应。成人时，几个miRNA在血清和大脑中受到影响，受创伤的动物及其后代受到影响，但在受创伤的雄性的精子中也受到影响。将这些雄性的精子RNA注入受精的野生型卵母细胞，再现了由此产生的后代的行为和代谢改变。这些结果强烈表明，SNCRNA对早期生命中的环境因素很敏感，并有助于跨几代人的创伤引起的表型的遗传。他们可能会为人类相关病理提供潜在的诊断标记。
Gene-environment interactions are determining factors for the etiology of psychiatric disorders, diabetes and cancer, and are thought to contribute to disease inheritance across generations. Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. Here, we report that environmental conditions involving traumatic stress in early life in mice altered microRNAs (miRNAs) expression, and behavioral and metabolic responses in the progeny. Several miRNAs were affected in the serum and brain of both, the traumatized animals and their progeny when adult, but also in the sperm of traumatized males. Injection of sperm RNAs from these males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring. These results strongly suggest that sncRNAs are sensitive to environmental factors in early life, and contribute to the inheritance of trauma-induced phenotypes across generations. They may offer potential diagnostic markers for associated pathologies in humans.
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影响因子：
14.9
作者：
Kozomara A;Griffiths-Jones S
通讯作者：
Griffiths-Jones S
影响因子：
4
作者：
Johnson, G. D.;Sendler, E.;Krawetz, S. A.
通讯作者：
Krawetz, S. A.
影响因子：
4.1
作者：
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通讯作者：
Herzig, Stephan
DOI：
10.1073/pnas.1113310108
发表时间：
2011-12-06
影响因子：
11.1
作者：
Burton, Nick O.;Burkhart, Kirk B.;Kennedy, Scott
通讯作者：
Kennedy, Scott
影响因子：
3.7
作者：
Franklin TB;Linder N;Russig H;Thöny B;Mansuy IM
通讯作者：
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