Structural biology of SARS-CoV-2: open the door for novel therapies.
Structural biology of SARS-CoV-2: open the door for novel therapies.
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SARS-CoV-2 的结构生物学：为新疗法打开大门
DOI：
10.1038/s41392-022-00884-5
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发表时间：
2022-01-27
影响因子：
39.3
通讯作者：
Cheng W
中科院分区：
文献类型：
--
作者：
Yan W;Zheng Y;Zeng X;He B;Cheng W
严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）是大流行性疾病COVID-19的病原体，迄今尚无有效的治疗方法。迫切需要发现用于治疗COVID-19的治疗试剂，而病毒生命周期中潜在药物靶蛋白的结构尤为重要。SARS冠状病毒2（SARS-CoV-2）是正冠状病毒亚科（Orthocoronavirinae）中RNA基因组最大的一个成员，编码29种蛋白，包括非结构蛋白、结构蛋白和辅助蛋白，这些蛋白参与病毒的吸附、进入和脱壳、核酸的复制和转录、装配和释放，这些蛋白质单独地作为复制机制的伙伴或参与与宿主细胞因子形成复合物以参与复制机制。基本的生理活动。本文综述了针对SARS冠状病毒2或病毒致病关键蛋白的典型结构和典型的潜在治疗药物，为深入了解病毒感染的机制、预防感染和治疗提供了依据。事实上，这些研究为COVID疗法打开了大门，从而找到了预防和治疗COVID-19的方法，特别是治疗由病毒变体引起的疾病势在必行。
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The discovery of therapy reagents for treating COVID-19 are urgently needed, and the structures of the potential drug-target proteins in the viral life cycle are particularly important. SARS-CoV-2, a member of the Orthocoronavirinae subfamily containing the largest RNA genome, encodes 29 proteins including nonstructural, structural and accessory proteins which are involved in viral adsorption, entry and uncoating, nucleic acid replication and transcription, assembly and release, etc. These proteins individually act as a partner of the replication machinery or involved in forming the complexes with host cellular factors to participate in the essential physiological activities. This review summarizes the representative structures and typically potential therapy agents that target SARS-CoV-2 or some critical proteins for viral pathogenesis, providing insights into the mechanisms underlying viral infection, prevention of infection, and treatment. Indeed, these studies open the door for COVID therapies, leading to ways to prevent and treat COVID-19, especially, treatment of the disease caused by the viral variants are imperative.
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DOI：
10.34172/bi.2020.27
发表时间：
2020
期刊：
BioImpacts : BI
影响因子：
--
作者：
Ansarin K;Tolouian R;Ardalan M;Taghizadieh A;Varshochi M;Teimouri S;Vaezi T;Valizadeh H;Saleh P;Safiri S;Chapman KR
通讯作者：
Chapman KR
影响因子：
6.7
作者：
Ahmed-Belkacem, Rostom;Sutto-Ortiz, Priscila;Debart, Francoise
通讯作者：
Debart, Francoise
影响因子：
4.9
作者：
Barton, Christopher;Kouokam, J. Calvin;Palmer, Kenneth E.
通讯作者：
Palmer, Kenneth E.
影响因子：
5.6
作者：
Bollati, Michela;Milani, Mario;Bolognesi, Martino
通讯作者：
Bolognesi, Martino
DOI：
10.1016/j.dsx.2020.04.020
发表时间：
2020-07-01
影响因子：
10
作者：
Astuti, Indwiani;Ysrafil
通讯作者：
Ysrafil