Neural self-representation in autistic women and association with 'compensatory camouflaging'.
Neural self-representation in autistic women and association with 'compensatory camouflaging'.
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DOI：
10.1177/1362361318807159
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发表时间：
2019-07
期刊：
影响因子：
--
通讯作者：
MRC AIMS Consortium
中科院分区：
文献类型：
--
作者：
Lai MC;Lombardo MV;Chakrabarti B;Ruigrok AN;Bullmore ET;Suckling J;Auyeung B;Happé F;Szatmari P;Baron-Cohen S;MRC AIMS Consortium
先前的工作揭示了跨行为和神经/生物领域的性/性别依赖性自闭症特征。目前尚不清楚神经性/性别差异是否以及如何与自闭症的行为性/性别差异有关。在这里，我们研究了非典型的神经反应在心智化和自我表征是否是性别/性别依赖的自闭症成年人，并探讨是否“老化”（行为神经典型）与性别/性别依赖的神经反应。总共，N = 119名成年人（33名典型的发展中男性，29名自闭症男性，29名典型的发展中女性和28名自闭症女性）参加了任务相关的功能性磁共振成像范例，以评估在心智化和自我表征过程中右颞顶叶交界处和腹内侧前额叶皮层内的神经激活。孤独症的伪装老化被量化为社会人际环境中的外在行为和内在状态之间的差异。虽然自闭症男性表现出低活性的右颞顶叶交界处心智化和腹内侧前额叶皮层自我表征的反应相比，典型的发展男性，这样的神经反应在自闭症女性没有什么不同，从典型的发展女性。仅在自闭症女性中，增加的年龄与腹内侧前额叶皮层自我表征反应的增强有关。与正常发育的女性相比，自闭症女性缺乏受损的神经自我表征和心智化。孤独症女性的伪装老化加剧，可能与神经自我表征反应有关。这些结果揭示了大脑行为的关系，有助于解释自闭症社会大脑功能的性别异质性。
Prior work has revealed sex/gender-dependent autistic characteristics across behavioural and neural/biological domains. It remains unclear whether and how neural sex/gender differences are related to behavioural sex/gender differences in autism. Here, we examined whether atypical neural responses during mentalizing and self-representation are sex/gender-dependent in autistic adults and explored whether ‘camouflaging’ (acting as if behaviourally neurotypical) is associated with sex/gender-dependent neural responses. In total, N = 119 adults (33 typically developing males, 29 autistic males, 29 typically developing females and 28 autistic females) participated in a task-related functional magnetic resonance imaging paradigm to assess neural activation within right temporo-parietal junction and ventromedial prefrontal cortex during mentalizing and self-representation. Camouflaging in autism was quantified as the discrepancy between extrinsic behaviour in social–interpersonal contexts and intrinsic status. While autistic men showed hypoactive right temporo-parietal junction mentalizing and ventromedial prefrontal cortex self-representation responses compared to typically developing men, such neural responses in autistic women were not different from typically developing women. In autistic women only, increasing camouflaging was associated with heightened ventromedial prefrontal cortex self-representation response. There is a lack of impaired neural self-representation and mentalizing in autistic women compared to typically developing women. Camouflaging is heightened in autistic women and may relate to neural self-representation response. These results reveal brain-behaviour relations that help explain sex/gender-heterogeneity in social brain function in autism.
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影响因子：
7.6
作者：
Joel, Daphna;McCarthy, Margaret M.
通讯作者：
McCarthy, Margaret M.
影响因子：
3.6
作者：
Hiller, Rachel M.;Young, Robyn L.;Weber, Nathan
通讯作者：
Weber, Nathan
影响因子：
3.9
作者：
Hull, Laura;Petrides, K. V.;Mandy, William
通讯作者：
Mandy, William
DOI：
10.1111/jcpp.12687
发表时间：
2017-04
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Jack A;A Pelphrey K
通讯作者：
A Pelphrey K
影响因子：
3.9
作者：
Hus, Vanessa;Lord, Catherine
通讯作者：
Lord, Catherine