Peak amplitude and resolution in comprehensive gas chromatography using valve modulation
Peak amplitude and resolution in comprehensive gas chromatography using valve modulation
复制标题
使用阀门调制的综合气相色谱中的峰值幅度和分辨率
DOI：
10.1002/jssc.200390079
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发表时间：
2003
影响因子：
5.4
通讯作者：
K. Bartle
中科院分区：
文献类型：
--
作者：
J. Hamilton;A. Lewis;K. Bartle
与单柱分离相比，全二维气相色谱(GC X GC)可显著提高峰容量。在GC x GC中连接两个色谱柱通常是通过热调制实现的。然而，通过阀门调制的分析物转移也是可能的，在阀门调制中，通过多孔阀将来自第一柱的部分引入第二柱。在本文中，我们发展了一个以前的峰值幅度增强模型，以比较热调制和阀门调制在GC x GC中可能的灵敏度和所产生的分辨率。虽然阀门调制产生的峰幅度不可避免地比热调制产生的峰值小得多，但与单柱GC相比仍有一定的提高。还比较了两种调制方法在GC×GC中的分辨率(R)，并预测对于来自第一维柱的部分分辨(R=1)窄峰的阀门调制，分辨率(R)一般会得到改善。以汽油蒸气的GC-X-GC分析为例，比较了热调制法和阀调制法在峰值增强和保留分辨率方面的差异。
Comprehensive two-dimensional gas chromatography (GC x GC) allows major increases in peak capacity in comparison with separations on a single column. Interfacing the two columns in GC x GC has most often been achieved by thermal modulation. However, analyte transfer by valve modulation, in which fractions from the first column are introduced into the second column by means of a multi-port valve, is also possible. In this paper we develop a previous model of peak amplitude enhancement to compare the sensitivity and resulting resolution possible in GC x GC with thermal and valve modulation. While the peak amplitude resulting from valve modulation is inevitably much less than in thermal modulation, there is still an enhancement in comparison to single column GC. Resolution (R) in GC x GC with the two modulation methods has also been compared and is predicted to be generally improved for the valve modulation of partially resolved (R= 1) narrow peaks from the first dimension column. A comparison of peak amplitude enhancement and retained resolution using thermal and valve modulation methods is made using the example of GC x GC analysis of gasoline vapour.
影响因子：
7.4
作者：
Opiteck, GJ;Lewis, KC;Anderegg, RJ
通讯作者：
Anderegg, RJ