Metabolites in the Tumor Microenvironment Reprogram Functions of Immune Effector Cells Through Epigenetic Modifications.
Metabolites in the Tumor Microenvironment Reprogram Functions of Immune Effector Cells Through Epigenetic Modifications.
复制标题
DOI：
10.3389/fimmu.2021.641883
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
Hu Y
中科院分区：
文献类型：
--
作者：
Li Y;Wu Y;Hu Y
近年来，肿瘤和免疫细胞在酸性、缺氧和营养耗尽的肿瘤微环境（TME）中的细胞代谢引起了越来越多的关注。越来越多的证据表明，TME中的癌细胞可以与免疫细胞竞争营养素，同时产生抑制免疫效应细胞功能的抑制性产物。最近的进展表明，TME中的代谢物可以通过干扰表观遗传程序和信号转导网络来失调免疫效应细胞的分化、增殖和活化中的基因表达模式。然而，令人鼓舞的研究表明，癌症和免疫效应细胞之间的代谢可塑性和异质性可以为我们提供发现和靶向癌细胞代谢脆弱性的机会，同时增强免疫效应细胞的抗肿瘤功能。在这篇综述中，我们将讨论代谢对TME中免疫效应细胞的影响，并探索代谢增强免疫疗法的治疗机会。
Cellular metabolism of both cancer and immune cells in the acidic, hypoxic, and nutrient-depleted tumor microenvironment (TME) has attracted increasing attention in recent years. Accumulating evidence has shown that cancer cells in TME could outcompete immune cells for nutrients and at the same time, producing inhibitory products that suppress immune effector cell functions. Recent progress revealed that metabolites in the TME could dysregulate gene expression patterns in the differentiation, proliferation, and activation of immune effector cells by interfering with the epigenetic programs and signal transduction networks. Nevertheless, encouraging studies indicated that metabolic plasticity and heterogeneity between cancer and immune effector cells could provide us the opportunity to discover and target the metabolic vulnerabilities of cancer cells while potentiating the anti-tumor functions of immune effector cells. In this review, we will discuss the metabolic impacts on the immune effector cells in TME and explore the therapeutic opportunities for metabolically enhanced immunotherapy.
登录
查看更多内容
影响因子：
64.5
作者：
Chang CH;Curtis JD;Maggi LB Jr;Faubert B;Villarino AV;O'Sullivan D;Huang SC;van der Windt GJ;Blagih J;Qiu J;Weber JD;Pearce EJ;Jones RG;Pearce EL
通讯作者：
Pearce EL
影响因子：
64.5
作者：
Buck MD;Sowell RT;Kaech SM;Pearce EL
通讯作者：
Pearce EL
影响因子：
50.3
作者：
Anderson KG;Stromnes IM;Greenberg PD
通讯作者：
Greenberg PD
影响因子：
7.8
作者：
Chaudhary B;Elkord E
通讯作者：
Elkord E
影响因子：
10.9
作者：
Alnaggar, Mohammed;Xu, Yan;Yin, Zhinan
通讯作者：
Yin, Zhinan