Acute effects of thalamic deep brain stimulation and thalamotomy on sensorimotor cortex local field potentials in essential tremor.
Acute effects of thalamic deep brain stimulation and thalamotomy on sensorimotor cortex local field potentials in essential tremor.
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DOI：
10.1016/j.clinph.2012.04.020
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Starr PA
中科院分区：
文献类型：
--
作者：
Air EL;Ryapolova-Webb E;de Hemptinne C;Ostrem JL;Galifianakis NB;Larson PS;Chang EF;Starr PA
特发性震颤（ET）的特征是一种动作性震颤，据信是由于小脑-丘脑-皮质系统中过度的θ-α活动所致。本研究旨在验证ET患者的治疗性丘脑刺激降低初级运动（M1）和感觉（S1）皮质的θ-α振荡活动的假设。在10例ET患者的手术治疗期间，皮质电图（ECoG）条形电极暂时放置在M1和S1的手臂区域上。局部场电位（LFP）记录在休息时，在震颤诱导的姿势，在急性治疗性丘脑刺激，治疗性丘脑切开术（3例）。使用快速傅立叶变换计算功率谱密度（PSD）。在静息状态下，M1的α活动（8-13 Hz）在高频刺激期间显著降低，而S1的θ活动（4-8 Hz）降低。丘脑切开术后，M1的θ和β（13-30 Hz）增加。与静息状态相比，姿势性震颤的诱导降低了M1 θ、α和β活性。高频丘脑脑深部电刺激（DBS）显著降低ET患者初级运动皮层的α振荡活动，尽管这种变化可能对治疗效果并不重要。我们证明，ECoG可以有效地用于研究皮层下刺激对皮层振荡的影响。
Essential tremor (ET) is characterized by an action tremor believed to be due to excessive theta–alpha activity in the cerebello–thalamo–cortical system. This study aimed to test the hypothesis that therapeutic thalamic stimulation in patients with ET decreases theta–alpha oscillatory activity in primary motor (M1) and sensory (S1) cortices. During surgical treatment of ET in 10 patients, an electrocorticography (ECoG) strip electrode was placed temporarily over the arm region of M1 and S1. Local field potentials (LFP) were recorded at rest, during a tremor-inducing posture, during acute therapeutic thalamic stimulation, and following therapeutic thalamotomy (three patients). Power spectral density (PSD) was calculated using the Fast Fourier Transform. At rest, alpha activity (8–13 Hz) in M1 was significantly decreased during high-frequency stimulation, while theta activity (4–8 Hz) decreased in S1. Following thalamotomy, theta and beta (13–30 Hz) was increased in M1. Induction of postural tremor reduced M1 theta, alpha and beta activity compared to the resting state. High-frequency thalamic deep brain stimulation (DBS) significantly reduces alpha oscillatory activity in the primary motor cortex of patients with ET, though this change is probably not critical for therapeutic efficacy. We demonstrate that ECoG can be effectively used to study the effect of subcortical stimulation on cortical oscillations.
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