Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases.
Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases.
复制标题
Corbrin胶囊对自身免疫性甲状腺疾病的双向免疫调节作用
DOI：
10.1155/2016/1360386
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Chen L
中科院分区：
文献类型：
--
作者：
He T;Zhao R;Lu Y;Li W;Hou X;Sun Y;Dong M;Chen L
目的。目的：研究冬虫夏草提取物柯布林胶囊(CS-C-Q80)的作用。对自身免疫性甲状腺疾病(AITD)的研究。方法：研究方法。将44例Graves病(GD)和56例桥本甲状腺炎(HT)患者随机分为治疗组(GD-TX和HT-TX)和对照组(GD-CT和HT-CT)。对照组单用他巴唑或左旋甲状腺素，治疗组在常规用药基础上加用柯布林胶囊(2.0 g， ，tid)。在基线和治疗24周后对甲状腺激素、甲状腺抗体和T淋巴细胞亚群进行量化。结果。GD-TX组和HT-TX组血清抗TPO-Ab水平均显著下降。治疗前，GD患者的辅助性T细胞高于细胞毒性T细胞，而HT患者的辅助性T/细胞毒性T细胞比例几乎倒置。经Corbrin治疗24周后，GD-TX患者辅助性T细胞/细胞毒性T细胞比例明显下降至正常范围的中位数，而HT-TX患者的辅助性T细胞/细胞毒性T细胞比例明显升高。结论。柯布林胶囊可恢复GD和HT患者辅助性T细胞和细胞毒性T细胞之间的平衡，具有双向免疫调节作用。能显著降低GD和HT患者的自身抗体水平。
Purpose. To investigate the effects of Corbrin Capsule (CS-C-Q80), a drug derived from Cordyceps sinensis (Berk.) Sacc., on autoimmune thyroid diseases (AITD). Methods. 44 Patients with Graves's disease (GD) and 56 patients with Hashimoto's thyroiditis (HT) were randomly assigned to treatment group (GD-Tx and HT-Tx) or control group (GD-Ct and HT-Ct). The control groups were given methimazole or levothyroxine only while the treatment groups were given Corbrin Capsule (2.0 g tid) besides the same conventional prescriptions as control groups. Thyroid hormones, thyroid antibodies, and T lymphocyte subsets were quantified at baseline and 24 weeks posttreatment. Results. Significant drop of serum anti-TPO-Ab levels was observed in both GD-Tx and HT-Tx groups. Before treatment, GD patients had higher helper T cells compared to cytotoxic T cells, while HT patients suffered from a nearly inverted proportion of helper T/cytotoxic T cells. There was a significant drop of the helper T/cytotoxic T cells ratio in GD-Tx to the median of the normal ranges after Corbrin treatment for 24 weeks, while that in HT-Tx was elevated. Conclusion. Corbrin Capsule could restore the balance between helper T and cytotoxic T cells in both GD and HT patients with dual-directional immunomodulatory effects. And it could significantly reduce the autoantibody levels in both GD and HT.
登录
查看更多内容
影响因子：
4.5
作者：
Lo HC;Hsieh C;Lin FY;Hsu TH
通讯作者：
Hsu TH
DOI：
10.1016/0090-1229(88)90075-x
发表时间：
1988-05-01
期刊：
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY
影响因子：
--
作者：
BAGNASCO, M;VENUTI, D;CANONICA, GW
通讯作者：
CANONICA, GW
影响因子：
3.5
作者：
MARTIN, A;GOLDSMITH, NK;ROMAN, SH
通讯作者：
ROMAN, SH
影响因子：
3.7
作者：
Chen X;May B;Di YM;Zhang AL;Lu C;Xue CC;Lin L
通讯作者：
Lin L
影响因子：
4.6
作者：
Okajima, M.;Wada, T.;Yachie, A.
通讯作者：
Yachie, A.