Mechanisms of disease: Helicobacter pylori virulence factors.
Mechanisms of disease: Helicobacter pylori virulence factors.
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DOI：
10.1038/nrgastro.2010.154
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发表时间：
2010-11
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
作者：
幽门螺杆菌在各种胃十二指肠疾病的发生发展中起着至关重要的作用，然而，只有一小部分人感染了幽门螺杆菌。幽门螺杆菌会导致这些疾病。一些人群中H.幽门螺杆菌感染也有胃癌的高发病率（例如，在东亚），而其他人则没有（例如，在非洲和南亚）。即使在东亚，胃癌的发病率也各不相同（在南部下降）。H.幽门螺杆菌是一种高度异质性的细菌，其毒力在地理上各不相同。胃癌发病率的地理差异可以解释，至少部分是由于存在不同类型的H。pylori毒力因子，尤其是CagA、VacA和OipA。然而，H.在进化过程中，pylori从非洲迁移到东亚时增加。H.幽门螺杆菌感染也被认为与十二指肠溃疡的发展有关，十二指肠溃疡与胃癌在疾病谱的另一端。这种差异可以部分地由H的存在来解释。幽门螺杆菌毒力因子DupA。尽管我们对H.幽门螺杆菌相关疾病，需要进一步的工作，以澄清H。pylori毒力因子
Helicobacter pylori plays an essential role in the development of various gastroduodenal diseases; however, only a small proportion of people infected with H. pylori develop these diseases. Some populations that have a high prevalence of H. pylori infection also have a high incidence of gastric cancer (for example, in East Asia), whereas others do not (for example, in Africa and South Asia). Even within East Asia, the incidence of gastric cancer varies (decreasing in the south). H. pylori is a highly heterogeneous bacterium and its virulence varies geographically. Geographic differences in the incidence of gastric cancer can be explained, at least in part, by the presence of different types of H. pylori virulence factor, especially CagA, VacA and OipA. However, it is still unclear why the pathogenicity of H. pylori increased as it migrated from Africa to East Asia during the course of evolution. H. pylori infection is also thought to be involved in the development of duodenal ulcer, which is at the opposite end of the disease spectrum to gastric cancer. This discrepancy can be explained in part by the presence of H. pylori virulence factor DupA. Despite advances in our understanding of the development of H. pylori-related diseases, further work is required to clarify the roles of H. pylori virulence factors.
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